4-氨基-5-硝基-6-氯嘧啶合成路线 （共 12 条）
参考文献
Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo
Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611
反应条件
1: N,N-dimethyl-formamide; 4,6-dihydroxy-pyrimidine With trichlorophosphate 2: With potassium permanganate in acetone 3: diazomethane
参考文献
Lee, Chih-Hung; Daanen, Jerome F; Jiang, Meiqun; Yu, Haixia; Kohlhaas, Kathy L; Alexander, Karen; Jarvis, Michael F; Kowaluk, Elizabeth L; Bhagwat, Shripad S
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 18 p. 2419 - 2422
反应条件
tin(ll) chloride in ethanol 1 h; Heating;
参考文献
Baraldi, Pier Giovanni; Broceta, Asier Unciti; Infantas, Maria Jose Pineda De Las; Mochun, Juan Jose Diaz; Espinosa, Antonio; Romagnoli, Romeo
Tetrahedron, 2002 , vol. 58, # 38 p. 7607 - 7611
参考文献
Boon; Jones
Journal of the Chemical Society, 1951 , p. 591,593
反应条件
triethylamine in N,N-dimethyl-formamide T=80°C; 4 h;
参考文献
Matsuno, Kenji; Ushiki, Junko; Seishi, Takashi; Ichimura, Michio; Giese, Neill A.; Yu, Jin-Chen; Takahashi, Shusuke; Oda, Shoji; Nomoto, Yuji
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 4910 - 4925
反应条件
sodium hydroxide; hydrogen sulfide; water
参考文献
Albert et al.
Journal of the Chemical Society, 1954 , p. 3832,3833
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Elion; Hitchings
Journal of the American Chemical Society, 1954 , vol. 76, p. 4027
Org.Synth.Isotopes, 1958 , p. 1939
反应条件
methanol; diethyl ether
参考文献
Almirante
Annali di Chimica (Rome, Italy), 1959 , vol. 49, p. 333,341
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Leese; Timmis
Journal of the Chemical Society, 1958 , p. 4107,4108
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Albert et al.
Journal of the Chemical Society, 1952 , p. 4219,4220
参考文献
Daly; Christensen
Journal of Organic Chemistry, 1956 , vol. 21, p. 177,178
参考文献
Daly; Christensen
Journal of Organic Chemistry, 1956 , vol. 21, p. 177,178
反应条件
sulfuric acid; sodium sulfite
参考文献
Okafor,C.O.
Journal of Organic Chemistry, 1975 , vol. 40, p. 2753 - 2755
