反应条件
1: 3,3-dibromo-1,1,1-trifluoropropanone With sodium acetate
0.5 h; Heating;
2: aminoguanidine hydrogen carbonate in water
T=20°C; pH=5; 3 h;
3: With sodium hydroxide
pH=10; 39 h;
参考文献
Russell, Michael G. N.; Carling, Robert W.; Street, Leslie J.; Hallett, David J.; Goodacre, Simon; Mezzogori, Elena; Reader, Michael; Cook, Susan M.; Bromidge, Frances A.; Newman, Robert; Smith, Alison J.; Wafford, Keith A.; Marshall, George R.; Reynolds, David S.; Dias, Rebecca; Ferris, Pushpindar; Stanley, Jo; Lincoln, Rachael; Tye, Spencer J.; Sheppard, Wayne F. A.; Sohal, Bindi; Pike, Andrew; Dominguez, Maria; Atack, John R.; Castro, Jose L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1235 - 1238