2-氧代-6-苯基-1,2-二氢-3-吡啶甲腈合成路线 （共 14 条）
反应条件
phosphorus pentachloride; trichlorophosphate T=150°C; 1 h;
参考文献
Honma; Sekine; Hashiyama; Takeda; Ono; Tsuzurahara
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 12 p. 4314 - 4324
反应条件
1: NBS / dimethylformamide / Heating 2: POCl3 / Heating 3: hydrazine hydrate / ethanol / 12 h / Heating View Scheme
参考文献
Witherington, Jason; Bordas, Vincent; Gaiba, Alessandra; Garton, Neil S.; Naylor, Antoinette; Rawlings, Anthony D.; Slingsby, Brian P.; Smith, David G.; Takle, Andrew K.; Ward, Robert W.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 18 p. 3055 - 3057
反应条件
hydrogen bromide in acetic acid 12 h; Heating;
参考文献
Damewood Jr.; Edwards; Feeney; Gomes; Steelman; Tuthill; Williams; Warner; Woolson; Wolanin; Veale
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3303 - 3312
反应条件
1: 93.8 percent / PCl5, POCl3 / 1 h / 150 °C
2: 1.) 90percent H2SO4; 2.) sodium nitrite / 1.) 120 deg C, 2 h; 2.) water, 80 deg C, 0.5 h
View Scheme
参考文献
Honma; Sekine; Hashiyama; Takeda; Ono; Tsuzurahara
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 12 p. 4314 - 4324
