7-羟基吡唑并[1,5-a]嘧啶-6-甲酸乙酯合成路线 (共 3 条)
反应条件
1: in ethanol T=20°C; 19 h; Heating / reflux; 2: With acetic acid in ethanol 57 h; Heating / reflux;
参考文献
Novartis AG
Patent: EP1918291 A1, 2008 ;
Location in patent: Page/Page column 22 ;
参考文献
Beecham Group Limited
Patent: US4081545 A1, 1978 ;
反应条件
N,N-diethylaniline; trichlorophosphate 3 h; Heating;
参考文献
Springer, Robert H.; Scholten, M. B.; O'Brien, Darrell E.; Novinson, Thomas; Miller, Jon P.; Robins, Roland K.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 235 - 242