2,3-二氢-1H-喹啉-4-酮合成路线 （共 51 条）
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in dichloromethane T=60°C; 16 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/52288 A1, 2009 ;
Location in patent: Page/Page column 395 ;
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; water
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US6017924 A1, 2000 ;
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; water
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5696133 A1, 1997 ;
反应条件
1: benzene; phenethylamine; ammonium chloride 2: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Johnson; Buell
Journal of the American Chemical Society, 1952 , vol. 74, p. 4513,4515
Journal of the American Chemical Society, 1952 , vol. 74, p. 4517,4519
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere 1.2: 12 h / 80 °C 2.1: cesium fluoride / acetonitrile / 24 h / 20 °C View Scheme
参考文献
Fang, Yuesi; Rogness, Donald C.; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2012 , vol. 77, # 14 p. 6262 - 6270
反应条件
sodium amalgam; ethanol T=55°C;
参考文献
Clemo; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 1618
反应条件
sodium azide; sulfuric acid 24 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Grunewald, Gary L.; Dahanukar, Vilas H.; Ching, Piao; Criscione, Kevin R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 18 p. 3539 - 3546
参考文献
Backeberg
Journal of the Chemical Society, 1933 , p. 618
反应条件
N-bromosuccinmide in dichloromethane T=20°C; 1.5 h;
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2005/87714 A2, 2005 ;
Location in patent: Page/Page column 125-126 ;
WO 2005/087714 A2
参考文献
Journal of the Chemical Society, , p. 1485,1490
