2,3-二氢-1H-喹啉-4-酮合成路线 （共 51 条）
反应条件
1: sodium t-butanolate / N,N-dimethyl-formamide / 2 h / 20 °C 2: trifluorormethanesulfonic acid / 1,2-dichloro-ethane View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
反应条件
1: copper(l) iodide; potassium carbonate / toluene / 20 h / 18 - 140 °C / Inert atmosphere; Sealed 2: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 - 18 °C / Inert atmosphere View Scheme
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: 41 percent / K2CO3 / ethanol / 24 h / Heating 2: 19 percent / polyphosphoric acid (PPA) / 0.25 h / 110 °C View Scheme
参考文献
Benincori, Tiziana; Brenna, Elisabetta; Sannicolo, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 9 p. 2139 - 2145
反应条件
1.1: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere 2.1: Jone's reagent / water; acetone / 1 h / 23 °C / Inert atmosphere 3.1: hydrogenchloride / 80 - 85 °C / Inert atmosphere 3.2: 1 h / 100 °C / Inert atmosphere View Scheme
参考文献
Bunce, Richard A.; Nammalwar, Baskar
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 613 - 619
反应条件
1.1: Jone's reagent / water; acetone / 1 h / 23 °C / Inert atmosphere 2.1: hydrogenchloride / 80 - 85 °C / Inert atmosphere 2.2: 1 h / 100 °C / Inert atmosphere View Scheme
参考文献
Bunce, Richard A.; Nammalwar, Baskar
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 613 - 619
反应条件
PPA T=120°C; 0.166667 h;
参考文献
Bakalova, Snezhana; Kavrakova, Ivanka
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1992 , vol. 47, # 12 p. 1775 - 1778
反应条件
hydrogenchloride; water
参考文献
Proctor; Thomson
Journal of the Chemical Society, 1957 , p. 2312
反应条件
ethanol; sodium; benzene
参考文献
Proctor; Thomson
Journal of the Chemical Society, 1957 , p. 3212
参考文献
Clemo; Perkin
Journal of the Chemical Society, 1924 , vol. 125, p. 1618
Full Text Show Details
Backeberg
Journal of the Chemical Society, 1933 , p. 618
反应条件
triethylamine in dichloromethane T=0°C; 16 h; Heating / reflux;
参考文献
WO2007/85558 A1, ;
Page/Page column 48-49 ;
