2,3-二氢-1H-喹啉-4-酮合成路线 （共 51 条）
反应条件
Acide polyphosphorique T=120 - 130°C; 1 h;
参考文献
Bellassoued-Fargeau, Marie-Claude; Graffe, Bernadette; Sacquet, Marie-Claude; Maitte, P.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 713 - 718
反应条件
trifluorormethanesulfonic acid in dichloromethane T=0 - 18°C; Fries rearrangement; 1 h; Inert atmosphere;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
methanesulfonic acid; phosphorous pentoxide T=130°C; 5 h; Inert atmosphere;
参考文献
Schering Corporation
Patent: US2011/312995 A1, 2011 ;
Location in patent: Page/Page column 50 ;
反应条件
1: acetic acid 2: pyridine 3: aqueous methanol. KOH-solution 4: phosphorus (V)-chloride; benzene / Behandeln des erhaltenen Reaktionsgemisches mit Zinn(IV)-chlorid in Benzol. 5: acetic acid; water; hydrochloric acid View Scheme
参考文献
Kano, Shinzo; Ebata, Tsutomu; Shibuya, Shiroshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2105 - 2111
反应条件
hydrogenchloride; acetic acid 3.5 h; Heating;
参考文献
Werbel, L. M.; Kesten, S. J.; Turner, W. R.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 11 p. 837 - 852
反应条件
1: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 2: 83 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Hueckel; Hagedorn
Chemische Berichte, 1957 , vol. 90, p. 752
反应条件
1: With hydrogenchloride T=80 - 85°C; Inert atmosphere; 2: With iron T=100°C; 1 h; Inert atmosphere;
参考文献
Bunce, Richard A.; Nammalwar, Baskar
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 3 p. 613 - 619
反应条件
1: pyridine / 0.33 h / Heating 2: aq. HCl / dioxane / 3 h / Heating 3: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 4: 83 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Johnson; Woroch; Buell
Journal of the American Chemical Society, 1949 , vol. 71, p. 1901,1905
反应条件
1: aq. HCl / dioxane / 3 h / Heating 2: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 3: 83 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Johnson; Woroch; Buell
Journal of the American Chemical Society, 1949 , vol. 71, p. 1901,1905
反应条件
PPA; Polyphosphoric acid (PPA) T=110°C; 0.25 h;
参考文献
Benincori, Tiziana; Brenna, Elisabetta; Sannicolo, Franco
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 9 p. 2139 - 2145
