2-氨基-4-甲氧基苯甲酸合成路线 （共 38 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=760.051 Torr; 18 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 112 ;
WO 2006/134378 A1
反应条件
hydrogenchloride in sodium hydroxide
参考文献
American Home Products Corporation
Patent: US5948775 A1, 1999 ;
US 5948775 A
反应条件
sodium hydroxide; dihydrogen peroxide 24 h; Ambient temperature;
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
ammonium hydroxide; hydrogen
参考文献
Sanofi Winthrop Inc.
Patent: US5488055 A1, 1996 ;
反应条件
in ammonium hydroxide
参考文献
Pfizer Inc.
Patent: US4287341 A1, 1981 ;
反应条件
1: 82 percent / H2NOH*HCl, Na2SO4*10H2O, conc. HCl / H2O / 0.17 h / Heating 2: 90 percent / PPA / 6 h / 55 - 60 °C 3: 35 percent / 30percent H2O2, aq. NaOH View Scheme
参考文献
Booker-Milburn, Kevin I.; Dunkin, Ian R.; Kelly, Frances C.; Khalaf, Abedawn I.; Learmonth, David A.; Proctor, George R.; Scopes, David I. C.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 21 p. 3261 - 3273
反应条件
1: 0.5 h / 165 °C 2: aq. NaOH; aq. H2O2 / 0.17 h / 100 °C View Scheme
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
反应条件
1: 66 percent / polyphosphoric acid / 0.17 h / 80 °C 2: 78 percent / aq. NaOH, 30percent H2O2 / 24 h / Ambient temperature View Scheme
参考文献
Cooke; Haynes
Australian Journal of Chemistry, 1958 , vol. 11, p. 225,228
反应条件
1: cycloheptatrienylium bromide 2: aq. KOH 3: (i) aq. KMnO4, MgSO4, (ii) aq. HBr, AcOH View Scheme
参考文献
Nozoe,T.; Takahashi,K.
Bulletin of the Chemical Society of Japan, 1967 , vol. 40, p. 1480 - 1487
参考文献
Friedlaender; Bruckner; Deutsch
Justus Liebigs Annalen der Chemie, 1912 , vol. 388, p. 34
