6-甲氧基-1,2,3,4-四氢异喹啉合成路线 （共 38 条）
反应条件
1: LiAlH4 / diethyl ether / Heating 2: HCl / ethanol / Heating View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
water; potassium hydroxide in ethanol Reflux;
参考文献
Leese, Mathew P.; Jourdan, Fabrice; Dohle, Wolfgang; Kimberley, Meriel R.; Thomas, Mark P.; Bai, Ruoli; Hamel, Ernest; Ferrandis, Eric; Potter, Barry V. L.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 1 p. 5 - 9
反应条件
1: toluene-4-sulfonic acid / toluene / 120 °C 2: water; potassium hydroxide / ethanol / Reflux View Scheme
参考文献
Leese, Mathew P.; Jourdan, Fabrice; Dohle, Wolfgang; Kimberley, Meriel R.; Thomas, Mark P.; Bai, Ruoli; Hamel, Ernest; Ferrandis, Eric; Potter, Barry V. L.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 1 p. 5 - 9
反应条件
1: LiAlH4 / diethyl ether / Heating 2: HCl / ethanol / Heating View Scheme
参考文献
Bojarski, Andrzej J; Mokrosz, Maria J; Minol, Sijka Charakchieva; Koziol, Aneta; Wesolowska, Anna; Tatarczynska, Ewa; Klodzinska, Aleksandra; Chojnacka-Wojcik, Ewa
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 1 p. 87 - 95
反应条件
1: AcOH / ethanol / 18 h / Heating 2: NaBH4 / methanol / 1 h / Ambient temperature 3: 90 percent / acetic anhydride / 1 h / 70 °C 4: 94 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature 5: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h 6: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 7: 91 percent / 10percent aq. NaOH / ethanol / 4 h / Heating View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 90 percent / acetic anhydride / 1 h / 70 °C 2: 94 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature 3: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h 4: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 5: 91 percent / 10percent aq. NaOH / ethanol / 4 h / Heating View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 94 percent / NaIO4 / H2O; methanol / 16 h / Ambient temperature 2: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h 3: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 91 percent / 10percent aq. NaOH / ethanol / 4 h / Heating View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 91 percent / 10percent aq. NaOH / ethanol / 4 h / Heating View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h 2: 65 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 91 percent / 10percent aq. NaOH / ethanol / 4 h / Heating View Scheme
参考文献
Shinohara, Tatsumi; Takeda, Akira; Toda, Jun; Ueda, Yoko; Kohno, Michiyo; Sano, Takehiro
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 6 p. 918 - 927
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 2: hydrogenchloride / water / 1 h / 60 °C 3: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 4: sodium hydrogencarbonate / water / 0.5 h / 20 °C View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
