1: acetyl chloride With aluminium trichloride in dichloromethane cooling; 2: thien-3-yl bromide in dichloromethane T=0 - 20°C; Friedel-Crafts acylation; 1.66667 h;
参考文献
Pelly, Stephen C.; Parkinson, Christopher J.; Van Otterlo, Willem A. L.; De Koning, Charles B.
Journal of Organic Chemistry, 2005 , vol. 70, # 25 p. 10474 - 10481
1: 2-Bromo-3-iodothiophene With ethyl magnesium chloride in tetrahydrofuran T=15°C; 0.25 h; 2: acetic anhydride in tetrahydrofuran T=20 - 25°C; 0.75 h; Title compound not separated from byproducts;
参考文献
Christophersen, Claus; Begtrup, Mikael; Ebdrup, Soren; Petersen, Henning; Vedso, Per
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9513 - 9516
