2’,3’-双脱氧双脱氢肌苷合成路线 （共 11 条）
反应条件
N-ethylpiperidine hypophosphite; triethyl borane in tetrahydrofuran; 1,4-dioxane; hexane T=20°C; 1 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP1634882 A1, 2006 ;
Location in patent: Page/Page column 13 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Chu; Bhadti; Doboszewski; Gu; Kosugi; Pullaiah; Van Roey
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2217 - 2225
反应条件
ammonia in methanol Ambient temperature;
参考文献
Talekar; Coe; Walker
Synthesis, 1993 , # 3 p. 303 - 306
反应条件
1: 90 percent / p-TsOH*H2O / dimethylsulfoxide / 5 h / Ambient temperature 2: 87 percent / acetonitrile / Ambient temperature 3: 51 percent / Zn/Cu / dimethylformamide / Ambient temperature 4: 61 percent / NH3 / methanol / Ambient temperature View Scheme
参考文献
Chu; Bhadti; Doboszewski; Gu; Kosugi; Pullaiah; Van Roey
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2217 - 2225
反应条件
ammonia 48 h; Ambient temperature;
参考文献
Dorland; Serafinowski
Synthesis, 1992 , # 5 p. 477 - 481
反应条件
1: 1.) aq. 5 N NaOH / 1.) DMSO 2: 85 percent / tri-n-butyltin hydride, azobisisobutyronitrile / toluene / 1 h / Heating 3: 67 percent / 1 M tetra-n-butylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Chu; Bhadti; Doboszewski; Gu; Kosugi; Pullaiah; Van Roey
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2217 - 2225
反应条件
1: 39 percent / triethyl phosphite / 0.5 h / Heating 2: 67 percent / 1 M tetra-n-butylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Chu; Bhadti; Doboszewski; Gu; Kosugi; Pullaiah; Van Roey
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2217 - 2225
反应条件
1: 85 percent / tri-n-butyltin hydride, azobisisobutyronitrile / toluene / 1 h / Heating 2: 67 percent / 1 M tetra-n-butylammonium fluoride / tetrahydrofuran View Scheme
参考文献
Chu; Bhadti; Doboszewski; Gu; Kosugi; Pullaiah; Van Roey
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2217 - 2225
反应条件
1: 87 percent / acetonitrile / Ambient temperature 2: 51 percent / Zn/Cu / dimethylformamide / Ambient temperature 3: 61 percent / NH3 / methanol / Ambient temperature View Scheme
参考文献
Talekar; Coe; Walker
Synthesis, 1993 , # 3 p. 303 - 306
反应条件
1: 51 percent / Zn/Cu / dimethylformamide / Ambient temperature 2: 61 percent / NH3 / methanol / Ambient temperature View Scheme
参考文献
Talekar; Coe; Walker
Synthesis, 1993 , # 3 p. 303 - 306
