L-丙氨酸苄酯对甲苯磺酸盐合成路线 （共 9 条）
反应条件
in benzene 10 h; RefluxInert atmosphere;
参考文献
Tayama, Eiji; Igarashi, Tomohito; Iwamoto, Hajime; Hasegawa, Eietsu
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 2 p. 339 - 345
反应条件
in tetrahydrofuran T=35°C; 2 h;
参考文献
Barlos, Kleomenis; Gatos, Dimitrios; Kallitsis, Ioannis; Papaioannou, Dionysios; Sotiriou, Petros
Liebigs Annalen der Chemie, 1988 , p. 1079 - 1082
参考文献
Biondini, Daniele; Brinchi, Lucia; Germani, Raimondo; Goracci, Laura; Savelli, Gianfranco
Letters in Organic Chemistry, 2010 , vol. 7, # 1 p. 39 - 44
反应条件
4-methyl-morpholine in methanol; cyclohexane
参考文献
DeGussa Aktiengesellschaft
Patent: US5387696 A1, 1995 ;
反应条件
triethylamine in chloroform T=20°C;
参考文献
Hayashida, Osamu; Sebo, Lubomir; Rebek Jr., Julius
The Journal of organic chemistry, 2002 , vol. 67, # 24 p. 8291 - 8298
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide
参考文献
Akazome, Motohiro; Hirabayashi, Atsushi; Takaoka, Kousuke; Nomura, Satoru; Ogura, Katsuyuki
Tetrahedron, 2005 , vol. 61, # 5 p. 1107 - 1113
反应条件
4-methyl-morpholine; chloroformic acid ethyl ester 1.) THF, -15 deg C, 5 min, 2.) CH2Cl2, -15 deg C, 4 h; room temperature, overnight; Yield given. Multistep reaction;
参考文献
Nakata; Takahashi; Nakatani; Kuramitsu; Tamura; Okai
Bioscience, biotechnology, and biochemistry, 1995 , vol. 59, # 4 p. 689 - 693
反应条件
1: 63 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole, N-ethylmorpholine / CH2Cl2 / -15 deg C, 1 h -> room temperature, 5 h
2: trifluoroacetic acid / 0.5 h / Ambient temperature
View Scheme
参考文献
Hagen; Bergan; Aasen
1984 , vol. 38, # 1 B p. 5 - 14
反应条件
4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane
T=0 - 20°C;
参考文献
Rich, Daniel H.; Kawai, Megumi; Goodman, Hedda L.; Suttie, John W.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 910 - 916
