6-氟-1,2,3,4-四氢-2-甲基喹啉合成路线 （共 12 条）
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate in dichloromethane T=25°C; 96 h;
参考文献
Bruckmann, Angelika; Pena, Miguel A.; Bolm, Carsten
Synlett, 2008 , # 6 p. 900 - 902
反应条件
ammonium acetate; platinum in hydrogenchloride; methanol; water; acetic acid; isopropyl alcohol; acetone; toluene
参考文献
Minnesota Mining and Manufacturing Company
Patent: US4301291 A1, 1981 ;
反应条件
PPA in water; toluene
参考文献
Minnesota Mining and Manufacturing Company
Patent: US4301289 A1, 1981 ;
Title/Abstract Full Text Show Details
Minnesota Mining and Manufacturing Company
Patent: US4301291 A1, 1981 ;
反应条件
in sodium hydroxide; toluene
参考文献
Minnesota Mining and Manufacturing Company
Patent: US4301289 A1, 1981 ;
Title/Abstract Full Text Show Details
Minnesota Mining and Manufacturing Company
Patent: US4301291 A1, 1981 ;
参考文献
S P A SOCIETA' PRODOTTI ANTIBIOTICI S.p.a.
Patent: EP310849 A1, 1989 ;
反应条件
1: 97 percent / 2.5 h / 125 °C 2: 69.1 percent / polyphosphoric acid / toluene / 6 h / 110 °C 3: 70.8 percent / H2O / 3 h / 100 °C View Scheme
参考文献
Balint, Jozsef; Egri, Gabriella; Fogassy, Elemer; Boecskei, Zsolt; Simon, Kalman; Gajary, Antal; Friesz, Antal
Tetrahedron Asymmetry, 1999 , vol. 10, # 6 p. 1079 - 1087
反应条件
C21H21ClIrNO2 in tetrahydrofuran; 2,2,2-trifluoroethanol 20 h; Inert atmosphere;
参考文献
Wu, Jianjun; Talwar, Dinesh; Johnston, Steven; Yan, Ming; Xiao, Jianliang
Angewandte Chemie - International Edition, 2013 , vol. 52, # 27 p. 6983 - 6987
Ross. Khim. Zh., 2013 , vol. 125, # 27 p. 7121 - 7125,5
反应条件
in dichloromethane
T=-20°C; 6 h; Resolution of racemate; Temperature;
参考文献
Gruzdev, Dmitry A.; Chulakov, Evgeny N.; Levit, Galina L.; Ezhikova, Marina A.; Kodess, Mikhail I.; Krasnov, Victor P.
Tetrahedron Asymmetry, 2013 , vol. 24, # 19 p. 1240 - 1246
反应条件
in dichloromethane
T=-20°C; 6 h; Resolution of racemate; Temperature;
参考文献
Gruzdev, Dmitry A.; Chulakov, Evgeny N.; Levit, Galina L.; Ezhikova, Marina A.; Kodess, Mikhail I.; Krasnov, Victor P.
Tetrahedron Asymmetry, 2013 , vol. 24, # 19 p. 1240 - 1246
反应条件
in dichloromethane
T=-20°C; 6 h; Resolution of racemate;
参考文献
Gruzdev, Dmitry A.; Chulakov, Evgeny N.; Levit, Galina L.; Ezhikova, Marina A.; Kodess, Mikhail I.; Krasnov, Victor P.
Tetrahedron Asymmetry, 2013 , vol. 24, # 19 p. 1240 - 1246
