(4-氨基-苯基)-磷酸二乙酯合成路线 （共 18 条）
反应条件
stannous chloride in dichloromethane
参考文献
Weigele, Manfred; Sawyer, Tomi K.; Bohacek, Regine; Shakespeare, William C.; Sundaramoorthi, Rajeswari; Wang, Yihan; Dalgarno, David C.; Metcalf III, Chester A.
Patent: US2002/68721 A1, 2002 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine
T=130°C; 20 h; Green chemistry;
参考文献
Wang, Ping; Lu, Jie; Zhang, Zhan-Hui
Journal of Chemical Research, 2013 , vol. 37, # 6 p. 359 - 361
反应条件
potassium tert-butylate in ammonia
3 h; Irradiation;
参考文献
Beugelmans, Rene; Chbani, Mohamed
Bulletin de la Societe Chimique de France, 1995 , vol. 132, p. 290 - 305
反应条件
palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether in tetrahydrofuran
T=25°C; Hirao reaction; 16 h; Inert atmosphereDarkness;
参考文献
Kohler, Mark C.; Sokol, Joseph G.; Stockland Jr., Robert A.
Tetrahedron Letters, 2009 , vol. 50, # 4 p. 457 - 459
反应条件
sodium ethanolate
12 h; Inert atmosphereReflux;
参考文献
Rehor, Ivan; Kubicek, Vojtech; Kotek, Jan; Hermann, Petr; Lukes, Ivan; Szakova, Jirina; Vander Elst, Luce; Muller, Robert N.; Peters, Joop A.
Journal of Materials Chemistry, 2009 , vol. 19, # 10 p. 1494 - 1500
反应条件
1: phosphonic acid diethyl ester With potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; Metallation; 0.166667 h;
2: 4-bromo-aniline in N,N-dimethyl-formamide
T=20°C; Substitution; 20 h; Irradiation;
参考文献
Defacqz, Nathalie; De Bueger, Bruno; Touillaux, Roland; Cordi, Alex; Marchand-Brynaert, Jacqueline
Synthesis, 1999 , # 8 p. 1368 - 1372
反应条件
N,N-dicyclohexylmethylamine; palladium diacetate; triphenylphosphine in ethanol
30 h; RefluxInert atmosphere;
参考文献
Bessmertnykh, Alla; Douaihy, Christiane Morkos; Guilard, Roger
Chemistry Letters, 2009 , vol. 38, # 7 p. 738 - 739
反应条件
copper(I) oxide; ammonium hydroxide
5 h; Heating;
参考文献
Buseck; Neidlein
Archiv der Pharmazie, 1993 , vol. 326, # 4 p. 193 - 197
反应条件
1: phosphonic acid diethyl ester With potassium tert-butylate in dimethyl sulfoxide
T=20°C; Metallation; 0.166667 h;
2: 2-fluoro-4-bromo-aniline in dimethyl sulfoxide
T=20°C; Substitution; 2 h; Irradiation;
参考文献
Defacqz, Nathalie; De Bueger, Bruno; Touillaux, Roland; Cordi, Alex; Marchand-Brynaert, Jacqueline
Synthesis, 1999 , # 8 p. 1368 - 1372
反应条件
1: phosphonic acid diethyl ester With potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; Metallation; 0.166667 h;
2: 1-Amino-2,4-dibromobenzene in N,N-dimethyl-formamide
T=20°C; Substitution; 5 h; Irradiation;
参考文献
Defacqz, Nathalie; De Bueger, Bruno; Touillaux, Roland; Cordi, Alex; Marchand-Brynaert, Jacqueline
Synthesis, 1999 , # 8 p. 1368 - 1372
