2-(4-硝基苯基)吡啶合成路线 （共 46 条）
反应条件
triphenylphosphine; copper(l) iodide; palladium diacetate in N,N-dimethyl-formamide T=80°C;
参考文献
WAKO PURE CHEMICAL INDUSTRIES, LTD.
Patent: US2010/87646 A1, 2010 ;
Location in patent: Page/Page column 18 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=95°C; Suzuki Coupling;
参考文献
ARRAY BIOPHARMA, INC.
Patent: WO2007/130743 A2, 2007 ;
Location in patent: Page/Page column 63 ;
WO 2007/130743 A2
反应条件
caesium carbonate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=80°C; 24 h;
参考文献
CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner
Patent: WO2014/27199 A1, 2014 ;
Location in patent: Page/Page column 78 ;
反应条件
1: in tetrahydrofuran Negishi coupling reaction; 0.0833333 h; 2: With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran Negishi coupling reaction; 16 h; Reflux;
参考文献
UTI LIMITED PARTNERSHIP; BERLINGUETTE, Curtis; BOMBEN, Paolo
Patent: WO2012/155247 A1, 2012 ;
Location in patent: Page/Page column 60-61 ;
反应条件
pyridine; copper(I) oxide; triphenylphosphine; PdI2 in 1-methyl-pyrrolidin-2-one T=50 - 190°C; 6 h; Microwave irradiationInert atmosphere;
参考文献
Haley, Christopher K.; Gilmore, Christopher D.; Stoltz, Brian M.
Tetrahedron, 2013 , vol. 69, # 27-28 p. 5732 - 5736
反应条件
2-methylamino-ethanol; copper(l) iodide; PdCl2dcpp in N,N-dimethyl-formamide T=100°C; Suzuki-Miyaura Coupling; 16 h; Inert atmosphere; Reagent/catalyst;
参考文献
Sakashita, Shohei; Takizawa, Miho; Sugai, Juugaku; Ito, Hajime; Yamamoto, Yasunori
Organic Letters, 2013 , vol. 15, # 17 p. 4308 - 4311
反应条件
tris(dibenzylideneacetone)dipalladium (0); [HP(t-Bu)3]BF4 in tetrahydrofuran T=175°C; Negishi cross-coupling; 0.166667 h; microwave irradiation;
参考文献
Walla, Peter; Kappe, C. Oliver
Chemical Communications, 2004 , # 5 p. 564 - 565
反应条件
1: para-nitro iodo-benzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.5 h; 2: pyridin-2-ylzinc bromide in tetrahydrofuran T=65°C; Negishi coupling reaction; 1 h;
参考文献
Coleridge, Brian M.; Bello, Charles S.; Ellenberger, David H.; Leitner, Andreas
Tetrahedron Letters, 2010 , vol. 51, # 2 p. 357 - 359
反应条件
palladium diacetate; potassium carbonate; triphenylphosphine; copper(l) iodide in tetrahydrofuran Suzuki-Miyaura cross-coupling reaction; Heating;
参考文献
Hodgson, Paul B.; Salingue, Fabrice H.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 685 - 687
反应条件
tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; silver(l) oxide in tetrahydrofuran; N,N-dimethyl-formamide T=90°C; 18 h;
参考文献
Napier, Spencer; Marcuccio, Sebastian M.; Tye, Heather; Whittaker, Mark
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6314 - 6315
