4-(4-硝基苯基)吡啶合成路线 （共 20 条）
反应条件
1: 4-(4'-nitrophenyl)pyridine With hydrogenchloride; hydrogen; platinum(IV) oxide in water T=25°C; 168 h; 2: di-tert-butyl dicarbonate With triethylamine in tetrahydrofuran T=0 - 25°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/23235 A1, 2008 ;
Location in patent: Page/Page column 59-60 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
参考文献
Agouron Pharmaceuticals, Inc.
Patent: EP1215208 A2, 2002 ;
Location in patent: Example C(122) ;
EP 1215208 A2
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate in 1,4-dioxane; water
T=80°C; 18 h; Inert atmosphere;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00564 ;
WO 2013/043232 A2
反应条件
palladium diacetate; triethylamine; tris-(o-tolyl)phosphine in acetonitrile
T=125°C; 20 h;
参考文献
Masselot, David; Charmant, Jonathan P. H.; Gallagher, Timothy
Journal of the American Chemical Society, 2006 , vol. 128, # 3 p. 694 - 695
反应条件
tetrabutyl ammonium fluoride; tri-cyclo-hexyl-phosphine; dichloro bis(acetonitrile) palladium(II)
T=85 - 90°C; Suzuki-Miyaura reaction; 5 h;
参考文献
Li, Jin-Heng; Deng, Chen-Liang; Xie, Ye-Xiang
Synthetic Communications, 2007 , vol. 37, # 14 p. 2433 - 2448
反应条件
triethylamine; tris-(o-tolyl)phosphine; palladium diacetate in acetonitrile
T=125°C; Heck reaction; 20 h;
参考文献
Karig, Gunter; Moon, Maria-Teresa; Thasana, Nopporn; Gallagher, Timothy
Organic Letters, 2002 , vol. 4, # 18 p. 3115 - 3118
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in 1,4-dioxane; water
T=100°C; 20 h;
参考文献
Portola Pharmaceuticals, Inc.; Song, Yonghong; Xu, Qing; Jia, Zhaozhong J.; Kane, Brian; Bauer, Shawn M.; Pandey, Anjali
Patent: US2013/131040 A1, 2013 ;
Location in patent: Paragraph 0359 ;
反应条件
potassium hydroxide; tetrabutylammomium bromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
2 h; Heating;
参考文献
Ishikura; Ohta; Terashima
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 11 p. 4755 - 4763
反应条件
sulfuric acid; nitric acid
T=100°C; 2 h;
参考文献
Wang, Yingsheng; Schanze, Kirk S.
Journal of Physical Chemistry, 1995 , vol. 99, # 18 p. 6876 - 6888
反应条件
in dimethyl sulfoxide
T=20°C; Arylation; 1 h;
参考文献
Gurczynski, Marek; Tomasik, Piotr
Organic Preparations and Procedures International, 1991 , vol. 23, # 4 p. 438 - 441
