2,2-二氟-1,3-丙二醇合成路线 （共 7 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 16 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=3;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong
Patent: WO2011/71716 A1, 2011 ;
Location in patent: Page/Page column 74 ;
WO 2011/071716 A1
反应条件
sodium methylate in methanol T=22°C; 2.5 h;
参考文献
Starrett, John E.; Tortolani, David R.; Russell, John; Hitchcock, Michael J. M.; Whiterock, Valerie; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1857 - 1864
反应条件
palladium 10 on activated carbon; hydrogen in propan-1-ol T=50°C; P=825.083 Torr; 24 h;
参考文献
Kim, Eunae; Shen, Guang Huan; Hong, Joon Hee
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 10 p. 798 - 813
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
McBee et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 444
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Fear et al.
Journal of the Chemical Society, 1956 , p. 3199,3202
反应条件
(i) KOAc, AcOH, Py, (ii) HCl, MeOH; Multistep reaction;
参考文献
Boguslavskaya,L.S. et al.
Journal of Organic Chemistry USSR (English Translation), 1971 , vol. 7, p. 1382 - 1387
Zhurnal Organicheskoi Khimii, 1971 , vol. 7, # 7 p. 1338 - 1343
反应条件
2,6-dimethylpyridine; trichlorophosphate in dichloromethane
18 h; Ambient temperature;
参考文献
Hunston, Roger N.; Jones, A. Stanley; McGuigan, Christopher; Walker, Richard T.; Balzarini, Jan; Clercq, Erik De
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 440 - 444
