2,4,6-三异丙基苯乙酸合成路线 （共 9 条）
反应条件
1: (COCl)2 2: 80 percent / TEA / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034
反应条件
potassium hydroxide; diethylene glycol
参考文献
Fuson; Armstrong; Shenk
Journal of the American Chemical Society, 1944 , vol. 66, p. 964,966
反应条件
1: pyridine / 210 - 220 °C
2: potassium hydroxide; water containing diethylene glycol
View Scheme
参考文献
Fuson; Armstrong; Shenk
Journal of the American Chemical Society, 1944 , vol. 66, p. 964,966
反应条件
1: 98 percent / LAH
2: 97 percent / PBr3 / diethyl ether
3: dimethylsulfoxide
4: aq. H2SO4
View Scheme
参考文献
Lee, Helen T.; Sliskovic, Drago R.; Picard, Joseph A.; Roth, Bruce D.; Wierenga, Wendell; Hicks, James L.; Bousley, Richard F.; Hamelehle, Katherine L.; Homan, Reynold; Speyer, Cecilia; Stanfield, Richard L.; Krause, Brian R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5031 - 5034
反应条件
1: 97 percent / PBr3 / diethyl ether
2: dimethylsulfoxide
3: aq. H2SO4
View Scheme
参考文献
Lee, Helen T.; Sliskovic, Drago R.; Picard, Joseph A.; Roth, Bruce D.; Wierenga, Wendell; Hicks, James L.; Bousley, Richard F.; Hamelehle, Katherine L.; Homan, Reynold; Speyer, Cecilia; Stanfield, Richard L.; Krause, Brian R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5031 - 5034
反应条件
1: dimethylsulfoxide
2: aq. H2SO4
View Scheme
参考文献
Lee, Helen T.; Sliskovic, Drago R.; Picard, Joseph A.; Roth, Bruce D.; Wierenga, Wendell; Hicks, James L.; Bousley, Richard F.; Hamelehle, Katherine L.; Homan, Reynold; Speyer, Cecilia; Stanfield, Richard L.; Krause, Brian R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5031 - 5034
反应条件
anschliessend Behandeln mit KOH;
参考文献
Fuson; Armstrong; Shenk
Journal of the American Chemical Society, 1944 , vol. 66, p. 964,966
反应条件
in N-methyl-acetamide
参考文献
Warner-Lambert Company
Patent: US5807846 A1, 1998 ;
反应条件
oxalyl dichloride
Yield given;
参考文献
Lee, Helen T.; Sliskovic, Drago R.; Picard, Joseph A.; Roth, Bruce D.; Wierenga, Wendell; Hicks, James L.; Bousley, Richard F.; Hamelehle, Katherine L.; Homan, Reynold; Speyer, Cecilia; Stanfield, Richard L.; Krause, Brian R.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 26 p. 5031 - 5034
