(R)-(-)-2-氨基-3-甲基-1-丁醇合成路线 (共 21 条)
反应条件
lithium borohydride; chloro-trimethyl-silane in tetrahydrofuran T=20°C; Reduction; 0.25 h;
参考文献
Quagliato, Dominick A.; Andrae, Patrick M.; Matelan, Edward M.
Journal of Organic Chemistry, 2000 , vol. 65, # 16 p. 5037 - 5042
反应条件
NaH; Fe(CO)5 in tetrahydrofuran; tetrachloromethane
反应条件
lithium aluminium tetrahydride in diethyl ether
参考文献
Journal of the Chemical Society, , p. 3965 - 3972
参考文献
Journal of the American Chemical Society, , vol. 106, # 25 p. 7729 - 7734
反应条件
sodium tetrahydroborate in ethanol; water 5.5 h; Heating;
参考文献
Agricultural and Biological Chemistry, , vol. 51, # 2 p. 537 - 548
反应条件
sodium tetrahydroborate
参考文献
Hirashima, Akinori; Eto, Morifusa
Agricultural and Biological Chemistry, 1983 , vol. 47, # 4 p. 829 - 838
参考文献
Synlett, , # 12 p. 1903 - 1905
反应条件
1: NaBH4 2: NaOH View Scheme
参考文献
Synlett, , # 12 p. 1903 - 1905
反应条件
1: 3-phenyl-propionaldehyde With 1-hydroxy-pyrrolidine-2,5-dione; oxygen; [Co(O2CCH3)2]*4H2O in acetonitrile T=20°C; P=760.051 Torr; 24 h; Molecular sieve; 2: (1R)-1-isopropyl-2-hydroxyethylamine in acetonitrile T=20°C; Molecular sieveInert atmosphere;
参考文献
Yao, Haoyi; Yamamoto, Kana
Chemistry - An Asian Journal, 2012 , vol. 7, # 7 p. 1542 - 1545
反应条件
1: With N(Et)4(1+)*(2-pyrrolidone-anion) in acetonitrile T=20°C; Carboxylation; 1 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=20°C; Cyclization; Further stages.;
参考文献
Casadei, M. Antonietta; Feroci, Marta; Inesi, Achille; Rossi, Leucio; Sotgiu, Giovanni
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4759 - 4761