1.1: B. lentus protease aqueous formulations / 8 h / 20 °C / pH 7 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.33 h / 0 - 12 °C / |Inert atmosphere 3.1: 4-(N,N-dimethlyamino)pyridine / pyridine / 5 - 50 °C 4.1: ozone / dichloromethane; methanol / -50 - -25 °C 4.2: -5 - 20 °C View Scheme

1.1: B. lentus protease aqueous formulations / 8 h / 20 °C / pH 7 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.33 h / 0 - 12 °C / |Inert atmosphere 3.1: 4-(N,N-dimethlyamino)pyridine / pyridine / 5 - 50 °C 4.1: ozone / dichloromethane; methanol / -50 - -25 °C 4.2: -5 - 20 °C 5.1: triethylamine / dichloromethane / 2.33 h / 0 - 5 °C View Scheme