3-羟基金刚烷-1-羧酸合成路线 （共 17 条）
反应条件
Yield given. Multistep reaction;
参考文献
Manchand; Cerruti; Martin; Hill; Merrett; Keech; Belshe; Connell; Sim
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1992 - 1995
反应条件
2: 62 percent / liq. NH3, H2 / Raney Ni / methanol / 6 h / 100 °C / 71107.8 Torr View Scheme
参考文献
Manchand; Cerruti; Martin; Hill; Merrett; Keech; Belshe; Connell; Sim
Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 1992 - 1995
反应条件
hydrogen bromide T=90°C; 3.5 h;
参考文献
Harman, David G.; Blanksby, Stephen J.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 21 p. 3495 - 3503
反应条件
tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate in acetone
T=20°C; 48 h;
参考文献
Kolocouris, Antonios; Hansen, Raino K.; Broadhurst, R. William
Journal of Medicinal Chemistry, 2004 , vol. 47, # 20 p. 4975 - 4978
反应条件
sulfuric acid in 1,2-dichloro-ethane
20 h; Heating;
参考文献
Adcock, William; Kok, Gaik B.
Journal of Organic Chemistry, 1987 , vol. 52, # 3 p. 356 - 364
反应条件
1-diethylamino-1,1-difluoro-2-chloro-2-fluoro-ethane; sodium hydroxide
Multistep reaction;
参考文献
Adcock, William; Kok, Gaik B.
Journal of Organic Chemistry, 1987 , vol. 52, # 3 p. 356 - 364
反应条件
hydrogen iodide
T=60°C; 16 h;
参考文献
Harman, David G.; Blanksby, Stephen J.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 21 p. 3495 - 3503
