6’-氯-2,3,5,6-四氢-[1,2’]联吡啶-4-羧酸叔丁酯合成路线 （共 4 条）
反应条件
triethylamine in acetonitrile T=120°C; 2 h; Microwave irradiation;
参考文献
ALMAC DISCOVERY LIMITED; HARRISON, Timothy; BURKAMP, Frank; JORDAN, Linda; BELL, Mark; JANSSEN, Dominic; MIEL, Hugues; MCFARLAND, Mary
Patent: WO2012/69852 A1, 2012 ;
Location in patent: Page/Page column 65 ;
反应条件
potassium carbonate in N,N-dimethylimidazolidin-2-one Heating / reflux;
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1396487 A1, 2004 ;
Location in patent: Page 14 ;
反应条件
1: With macroporous polymer-supported carbonate in dimethyl sulfoxide T=100°C; 2: With macroporous polymer-supported isocyanate in dichloromethane T=60°C;
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
反应条件
1: With macroporous polymer-supported-SO3H in dichloromethane T=20°C; 2: With ammonium hydroxide in methanol
参考文献
Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552
