3-[4-(三氟甲基）苯基]吡啶合成路线 （共 18 条）
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide
T=80°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
sodium hydroxide; tetrabutylammomium bromide; 4,4'-dichlorobenzophenone oxime-derived palladacycle
T=120°C; Hiyama coupling; P=7500.6 Torr; 0.166667 h; microwave irradiation;
参考文献
Alacid, Emilio; Najera, Carmen
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 945 - 952
反应条件
potassium carbonate in isopropyl alcohol
T=85 - 90°C; Suzuki-Miyaura Coupling; 24 h;
参考文献
Santra, Subhankar; Hota, Pradip Kumar; Bhattacharyya, Rangeet; Bera, Parthasarathi; Ghosh, Prasenjit; Mandal, Swadhin K.
ACS Catalysis, 2013 , vol. 3, # 12 p. 2776 - 2789
反应条件
Pd0(tris(tert-butyl)phosphine)2 in toluene
T=90°C; Inert atmosphere;
参考文献
Denmark, Scott E.; Smith, Russell C.; Chang, Wen-Tau T.; Muhuhi, Joseck M.
Journal of the American Chemical Society, 2009 , vol. 131, # 8 p. 3104 - 3118
反应条件
1: dihydroxy-4-(trifluoromethyl)phenylborane T=95°C; 12 h; dehydrationvacuum;
2: 3-(N,N-diethylcarbamoyloxy)-pyridine With potassium phosphate; NiCl2(PCy3)2; PCy3∙HBF4 in o-xylene
T=150°C; Suzuki-Miyaura coupling; 20 h; Inert atmosphere;
参考文献
Antoft-Finch, Aurora; Blackburn, Tom; Snieckus, Victor
Journal of the American Chemical Society, 2009 , vol. 131, # 49 p. 17750 - 17752
反应条件
potassium carbonate; cyclopallated ferrocenylimine c in water; N,N-dimethyl-formamide
T=110°C; Suzuki cross-coupling reaction; 10 h;
参考文献
Zhang, Jinli; Zhao, Liang; Song, Maoping; Mak, Thomas C.W.; Wu, Yangjie
Journal of Organometallic Chemistry, 2006 , vol. 691, # 6 p. 1301 - 1306
反应条件
sodium hydroxide; [PdCl2(P(3,4-(18-crown-6)-phenyl)2(C6H5))2]
T=140°C; 1.5 h;
参考文献
Gordillo, Alvaro; De Jesus, Ernesto; Lopez-Mardomingo, Carmen
Organic Letters, 2006 , vol. 8, # 16 p. 3517 - 3520
反应条件
1: With palladium diacetate; xantphos in N-dodecane; butan-1-ol
T=25°C; Suzuki-Miyaura Coupling; 0.0833333 h; Inert atmosphereGlovebox;
2: With cesium hydroxide monohydrate in N-dodecane; water; butan-1-ol
T=80°C; Suzuki-Miyaura Coupling; 4 h; Inert atmosphereGlovebox;
参考文献
Yang, Junfeng; Liu, Sijia; Zheng, Jian-Feng; Zhou, Jianrong
European Journal of Organic Chemistry, 2012 , # 31 p. 6248 - 6259,12
Title/Abstract Full Text Show Details
Yang, Junfeng; Liu, Sijia; Zheng, Jian-Feng; Zhou, Jianrong
European Journal of Organic Chemistry, 2012 , # 31 p. 6248 - 6259
反应条件
potassium phosphate; palladium dichloride; S-2,2',6,6'-tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine in butan-1-ol
T=100°C; Suzuki coupling; 20 h; Inert atmosphere;
参考文献
Fu, Xing-Li; Wu, Lei-Lei; Fu, Hai-Yan; Chen, Hua; Li, Rui-Xiang
European Journal of Organic Chemistry, 2009 , # 13 p. 2051 - 2054
反应条件
sodium hydroxide; palladium diacetate
T=60°C; Hiyama reaction; 9 h;
参考文献
Shi, Shengyin; Zhang, Yuhong
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5927 - 5930
