苯并[b]呋喃-2-甲醛合成路线 （共 56 条）
反应条件
1: pyridine
2: 1.) thionyl chloride / 1.) 100 deg C, 30 min; 2.) 70 deg C, 100 deg C, 15 min
3: 70 percent / trimethylbenzyl ammonium hydroxide / 16 h / 70 °C
4: 80 percent / hydrogen / Raney nickel / ethanol / 60 °C
5: 70 percent / CH2Cl2 / 1 h
6: ethanol / 24 h / Heating
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: pyridine
2: 1.) thionyl chloride / 1.) 100 deg C, 30 min; 2.) 70 deg C, 100 deg C, 15 min
3: 70 percent / trimethylbenzyl ammonium hydroxide / 16 h / 70 °C
4: 80 percent / hydrogen / Raney nickel / ethanol / 60 °C
5: 70 percent / CH2Cl2 / 1 h
6: 69 percent / ethanol / 24 h / Heating
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: 80 percent / H2NOH*HCl; pyridine; Ac2O / 2 h / 85 - 95 °C
2: 93 percent / AlCl3 / CH2Cl2
3: 14 percent / PhI(O2CMe)2 / toluene / 60 °C
4: 89 percent / aniline / toluene / 110 °C
View Scheme
参考文献
Bobosikova; Clegg; Coles; Dandarova; Hursthouse; Kiss; Krutosikova; Liptaj; Pronayova; Ramsden
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 8 p. 680 - 689
反应条件
1: 64 percent / sodium ethoxide / 1 h / 10 °C
2: 96 percent / toluene / 0.33 h / Heating
3: 79 percent / hydrazin hydrate 80percent / methanol / 40 h / Heating
4: 94 percent / dimethylformamide / 2.5 h / Heating
View Scheme
参考文献
Krutosikova; Kovac; Dandarova; Bobalova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 12 p. 3288 - 3296
反应条件
1: 99 percent / piperidine / toluene / 4 h / Heating
2: 92 percent / trimethylbenzyl ammonium hydroxyde / methanol / 24 h
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
piperidine in toluene
4 h; Heating;
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: 99 percent / piperidine / toluene / 4 h / Heating
2: 92 percent / trimethylbenzyl ammonium hydroxyde / methanol / 24 h
3: 97 percent / hydrogen / Raney nickel / ethanol / 3 h / 80 °C / 45003.6 Torr
4: 1.) sodium; 2.) 6N HCl / 1.) ethanol, water, 31 deg C, 2h; 2.) water, 60 deg C, 1 h
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: 99 percent / piperidine / toluene / 4 h / Heating
2: 92 percent / trimethylbenzyl ammonium hydroxyde / methanol / 24 h
3: 97 percent / hydrogen / Raney nickel / ethanol / 3 h / 80 °C / 45003.6 Torr
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
potassium tert-butylate in ethylene glycol dimethyl ether
参考文献
Merour, J. Y.; Buzas, A.
Synthetic Communications, 1988 , vol. 18, # 18 p. 2331 - 2336
反应条件
1: hydrazine hydrate / anschliessend mit Kaliumhydroxid
2: phosphoryl chloride
View Scheme
参考文献
Bisagni et al.
Journal of the Chemical Society, 1955 , p. 3688,3692
