苯并[b]呋喃-2-甲醛合成路线 （共 56 条）
反应条件
1: With sodium methylate in methanol T=20°C; 1 h; 2: With water; potassium hydroxide in methanol T=20°C; 3: With potassium dihydrogenphosphate in methanol; dichloromethane; water T=30°C; 3 h;
参考文献
Zhang, Chun; Zhang, Liangren; Jiao, Ning
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 7 p. 1293 - 1300
反应条件
1: NaBH4 / methanol / 20 °C
2: SOCl2; benzotriazole / CH2Cl2
View Scheme
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
sodium hydroxide; zinc diiodide in water
参考文献
Beecham Group Limited
Patent: US4432993 A1, 1984 ;
反应条件
1: 80 percent / H2NOH*HCl; pyridine; Ac2O / 2 h / 85 - 95 °C
2: 93 percent / AlCl3 / CH2Cl2
View Scheme
参考文献
Bobosikova; Clegg; Coles; Dandarova; Hursthouse; Kiss; Krutosikova; Liptaj; Pronayova; Ramsden
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 8 p. 680 - 689
反应条件
1: water / 0.03 h / Ultrasound irradiation
2: N-bromosuccinmide / water / 0.25 h / 65 - 70 °C / Ultrasound irradiation
View Scheme
参考文献
Sant' Anna, Gabriela da S.; Machado, Pablo; Sauzem, Patricia D.; Rosa, Fernanda A.; Rubin, Maribel A.; Ferreira, Juliano; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A.P.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 546 - 549
反应条件
in hexane; N,N-dimethyl-formamide
参考文献
Toyama Chemical Co., Ltd.
Patent: US5166204 A1, 1992 ;
反应条件
sodium ethanolate in diethyl ether; N,N-dimethyl-formamide
4 h; Ambient temperature;
参考文献
Landelle; Godard; Laduree; Chenu; Robba
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 3057 - 3060
反应条件
1: pyridine
2: 1.) thionyl chloride / 1.) 100 deg C, 30 min; 2.) 70 deg C, 100 deg C, 15 min
3: 70 percent / trimethylbenzyl ammonium hydroxide / 16 h / 70 °C
4: 80 percent / hydrogen / Raney nickel / ethanol / 60 °C
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: pyridine
2: 1.) thionyl chloride / 1.) 100 deg C, 30 min; 2.) 70 deg C, 100 deg C, 15 min
3: 70 percent / trimethylbenzyl ammonium hydroxide / 16 h / 70 °C
4: 80 percent / hydrogen / Raney nickel / ethanol / 60 °C
5: 70 percent / CH2Cl2 / 1 h
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
反应条件
1: pyridine
2: 1.) thionyl chloride / 1.) 100 deg C, 30 min; 2.) 70 deg C, 100 deg C, 15 min
3: 70 percent / trimethylbenzyl ammonium hydroxide / 16 h / 70 °C
4: 80 percent / hydrogen / Raney nickel / ethanol / 60 °C
5: 70 percent / CH2Cl2 / 1 h
6: ethanol / 20 h / Heating
View Scheme
参考文献
Maillard; Langlois; Vo Van; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 353 - 358
