2-氯-5-碘-3-氨基吡啶合成路线 （共 6 条）
反应条件
hydrogen in tetrahydrofuran T=37°C; P=2250.23 Torr; 12 h; chemoselective reaction;
参考文献
Kasparian, Annie J.; Savarin, Cecile; Allgeier, Alan M.; Walker, Shawn D.
Journal of Organic Chemistry, 2011 , vol. 76, # 23 p. 9841 - 9844
反应条件
1.1: H5IO6; H2SO4; aq. AcOH / 0.25 h / 90 °C 1.2: 99 percent / I2 / 1 h 2.1: conc. HCl; NaNO2 2.2: 36 percent / CuCl 3.1: 92 percent / conc. HCl; Fe / ethanol; H2O / 0.33 h / 100 °C View Scheme
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
反应条件
1.1: conc. HCl; NaNO2 1.2: 36 percent / CuCl 2.1: 92 percent / conc. HCl; Fe / ethanol; H2O / 0.33 h / 100 °C View Scheme
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
反应条件
1: 68 percent / I2; H5IO6 2: 88 percent / POCl3 3: 91 percent / SnCl2 View Scheme
参考文献
Zhang, Nanjing; Tomizawa, Motohiro; Casida, John E.
Bioorganic & Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 525 - 528
反应条件
1: 88 percent / POCl3 2: 91 percent / SnCl2 View Scheme
参考文献
Zhang, Nanjing; Tomizawa, Motohiro; Casida, John E.
Bioorganic & Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 525 - 528
反应条件
hydrogenchloride; sodium nitrite; copper(l) chloride
参考文献
Research Triangle Institute
Patent: US6538010 B1, 2003 ;
