3-(4-硝基苯基)-1,2-恶唑合成路线 （共 14 条）
反应条件
1: With TsNHOH; potassium carbonate in methanol; water
T=20°C; 1 h;
2: With potassium carbonate in methanol; water
T=60°C; 1 h; regioselective reaction;
参考文献
Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong
Organic Letters, 2009 , vol. 11, # 17 p. 3982 - 3985
反应条件
sodium methylate in methanol
Heating;
参考文献
Di Nunno, L.; Scilimati, A.
Tetrahedron, 1987 , vol. 43, # 9 p. 2181 - 2190
反应条件
sodium hypochlorite in tetrahydrofuran; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/83205 A1, 2004 ;
Location in patent: Page 51 ;
WO 2004/083205 A1
反应条件
1: 4-nitrobenzaldoxime With N-chloro-succinimide in chloroform
T=20°C; 0.333333 h;
2: polystyrene-supported vinyl selenide With triethylamine in dichloromethane
T=20°C; 12 h;
3: With dihydrogen peroxide in tetrahydrofuran
T=20°C; 0.5 h; Further stages.;
参考文献
Sheng, Shou-Ri; Xin, Qin; Liu, Xiao-Ling; Sun, Wu-Kang; Guo, Rui; Huang, Xian
Synthesis, 2006 , # 14 p. 2293 - 2296
反应条件
1: With triethylamine in chloroform
T=20°C; 12 h;
2: With dihydrogen peroxide in chloroform
T=20°C; 0.333333 h;
参考文献
Sheng, Shou-Ri; Liu, Xiao-Ling; Xu, Qu; Song, Cai-Sheng
Synthesis, 2003 , # 18 p. 2763 - 2764
反应条件
1: 63 percent / tetrahydrofuran / 4 h / Ambient temperature
2: 90 percent / 36percent H2O2/HCOOH / 4.75 h / 20 °C
View Scheme
参考文献
Bianchetti, Giuseppe; Pocar, Donato; Torricelli, Clara; Arlandini, Emanuele; Gioia, Bruno
Gazzetta Chimica Italiana, 1981 , vol. 111, # 7/8 p. 315 - 324
反应条件
1.1: N-chlorosuccinimide / CHCl3 / 0.33 h / 20 °C
2.1: Et3N / CHCl3 / 12 h / 20 °C
2.2: aq. H2O2 / CHCl3 / 0.33 h / 20 °C
View Scheme
参考文献
Sheng, Shou-Ri; Liu, Xiao-Ling; Xu, Qu; Song, Cai-Sheng
Synthesis, 2003 , # 18 p. 2763 - 2764
反应条件
triethylamine in chloroform
参考文献
Sokolov,S.D. et al.
Journal of Organic Chemistry USSR (English Translation), 1971 , vol. 7, p. 2051 - 2055
Zhurnal Organicheskoi Khimii, 1971 , vol. 7, p. 1979 - 1984
反应条件
1: With triethylamine in trichloroethane, 1,1,2-
0.5 h; Heating;
2: With sodium hydroxide
0.5 h; Heating;
参考文献
Schofield, Mark H.; Sorel, Marie-Adele; Manalansan, Ryan J.; Richardson, David P.; Markgraf, J. Hodge
Magnetic Resonance in Chemistry, 2006 , vol. 44, # 9 p. 851 - 855
反应条件
in benzene
Ambient temperature;
参考文献
Cristina, D.; Amici, M. De; Micheli, C. De; Gandolfi, R.
Tetrahedron, 1981 , vol. 37, p. 1349 - 1357
