3-(3-硝基-苯基)-异噁唑合成路线 （共 8 条）
反应条件
1: 3-nitrobenzaldehyde oxime With N-chloro-succinimide in DMF (N,N-dimethyl-formamide)
T=60°C; 3 h;
2: trans vinyl bromide With triethylamine in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 2 h;
参考文献
NEUROSEARCH A/S
Patent: WO2004/87137 A1, 2004 ;
Location in patent: Page/Page column 16 ;
WO 2004/087137 A1
反应条件
1: 3-nitro-benzaldehyde oxime With N-chloro-succinimide in DMF (N,N-dimethyl-formamide)
T=60°C; 3 h;
2: trans vinyl bromide With triethylamine in DMF (N,N-dimethyl-formamide)
T=0 - 20°C;
参考文献
NEUROSEARCH A/S
Patent: WO2004/87690 A2, 2004 ;
Location in patent: Page 22 ;
WO 2004/087690 A2
反应条件
hydroxylamine hydrochloride in methanol
3 h; Reflux;
参考文献
GLENMARK PHARMACEUTICALS, S.A.
Patent: WO2009/90548 A2, 2009 ;
Location in patent: Page/Page column 39 ;
WO 2009/090548 A2
反应条件
sodium methylate in methanol
Heating;
参考文献
Di Nunno, L.; Scilimati, A.
Tetrahedron, 1987 , vol. 43, # 9 p. 2181 - 2190
反应条件
in toluene
T=110°C; 2 h;
参考文献
Baranski, Andrzej; Shvekhgeimer, Genrikh A.
Polish Journal of Chemistry, 1982 , vol. 56, # 3 p. 459 - 467
反应条件
1: diethyl ether / 12 h / Ambient temperature
2: 84 percent / toluene / 2 h / 110 °C
View Scheme
参考文献
Baranski, Andrzej; Shvekhgeimer, Genrikh A.
Polish Journal of Chemistry, 1982 , vol. 56, # 3 p. 459 - 467
反应条件
1: triethylamine / diethyl ether / 0.17 h / -5 °C
2: diethyl ether / 12 h / Ambient temperature
3: 84 percent / toluene / 2 h / 110 °C
View Scheme
参考文献
Baranski, Andrzej; Shvekhgeimer, Genrikh A.
Polish Journal of Chemistry, 1982 , vol. 56, # 3 p. 459 - 467
反应条件
hydrogen; 5-palladium/activated carbon in ethanol
参考文献
NEUROSEARCH A/S
Patent: WO2004/87690 A2, 2004 ;
Location in patent: Page 23 ;
WO 2004/087690 A2
