反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 0.83 h / -70 - -60 °C / Inert atmosphere 1.2: 0.67 h / -70 °C / Inert atmosphere 1.3: Inert atmosphere 2.1: manganese(IV) oxide / dichloromethane / 1.5 h / 20 °C 3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -70 °C / Inert atmosphere 3.2: -70 - -30 °C / Inert atmosphere 3.3: -50 °C / Inert atmosphere 4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / -15 - 0 °C 5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 - 10 °C 6.1: acetonitrile / 0.33 h / 70 °C 6.2: 6 h / 70 °C 7.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -78 °C / Inert atmosphere 7.2: 16 h / 0 - 20 °C / Inert atmosphere 7.3: Inert atmosphere 8.1: ethanol 9.1: sodium hydroxide / water View Scheme
参考文献
Ruchelman, Alexander L.; Man, Hon-Wah; Chen, Roger; Liu, Wei; Lu, Ling; Cedzik, Dorota; Zhang, Ling; Leisten, Jim; Collette, Alice; Narla, Rama Krishna; Raymon, Heather K.; Muller, George W.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6356 - 6374
