9-苄基-9h-嘌呤-6-胺合成路线 （共 43 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=20 - 60°C; 25 h;
参考文献
Lambertucci, Catia; Antonini, Ippolito; Buccioni, Michela; Dal Ben, Diego; Kachare, Dhuldeo D.; Volpini, Rosaria; Klotz, Karl-Norbert; Cristalli, Gloria
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 7 p. 2812 - 2822
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Bliman, David; Pettersson, Mariell; Bood, Mattias; Grotli, Morten
Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2929 - 2931
反应条件
1: 6-aminopurine With sodium hydride in N,N-dimethyl-formamide T=20 - 60°C; 1 h; 2: benzyl bromide in N,N-dimethyl-formamide T=60°C; 24 h;
参考文献
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
Patent: WO2007/106450 A2, 2007 ;
Location in patent: Page/Page column 60; 64; 69 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in water; benzene T=80 - 83°C; 12 h;
参考文献
Thoiss
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1889 , vol. 13, p. 398
Full Text Show Details
Krueger
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1894 , vol. 18, p. 424,425
反应条件
ammonia in methanol T=90°C; 7 h;
参考文献
Laufer, Stefan A.; Domeyer, David M.; Scior, Thomas R. F.; Albrecht, Wolfgang; Hauser, Dominik R. J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 710 - 722
反应条件
1: 6-aminopurine With potassium carbonate in N,N-dimethyl-formamide T=105 - 110°C; 0.5 h; Heating; 2: benzyl chloride in N,N-dimethyl-formamide Heating;
参考文献
Petrov; Ozerov; Novikov; Pannecouque; Balzarini; De Clercq
Chemistry of Heterocyclic Compounds, 2003 , vol. 39, # 9 p. 1218 - 1226
反应条件
solution aqueuse d'hydroxide de sodium; tetrabutylammomium bromide in benzene 12 h; Heating;
参考文献
Hedayatullah, Mir
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 249 - 251
反应条件
potassium hydroxide; Aliquatreg; 336 in neat (no solvent) 3 h; Ambient temperature;
参考文献
Siah, Huey-San Melanie; Gundersen, Lise-Lotte
Synthetic Communications, 2013 , vol. 43, # 11 p. 1469 - 1476
反应条件
hydrogen; nickel in ethanol P=2275.5 Torr; 18 h;
参考文献
Hosmane, Ramachandra S.; Lim, Benjamin B.; Burnett, Friedrich N.
Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 382 - 386
反应条件
1: 1-methylguanidine hydrochloride With sodium methylate in methanol T=0°C; 0.333333 h; 2: 1-benzyl-4-cyano-5-lt;(methoxymethylene)aminogt;imidazole With aniline hydrochloric acid T=20°C; 20 h;
参考文献
Sun; Hosmane
Synthetic Communications, 2001 , vol. 31, # 4 p. 549 - 554
