2-苯基-1,1,1-三氟丙烷-2-醇合成路线 （共 19 条）
反应条件
phosphorus pentoxide
参考文献
Suprun
Journal fuer Praktische Chemie - Practical Applications and Applied Chemistry (Germany), 1999 , vol. 341, # 1 p. 52 - 58
反应条件
1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) in tetrahydrofuran; hexane
T=40°C; 3 h; Inert atmosphere;
参考文献
Zhang, Yuan; Fujiu, Motohiro; Serizawa, Hiroki; Mikami, Koichi
Journal of Fluorine Chemistry, 2013 , vol. 156, p. 367 - 371
反应条件
1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2Λ54Λ5-catenadi(phosphazene) in tetrahydrofuran; hexane
T=-40 - 40°C; Inert atmosphere;
参考文献
Zhang, Yuan; Fujiu, Motohiro; Serizawa, Hiroki; Mikami, Koichi
Journal of Fluorine Chemistry, 2013 , vol. 156, p. 367 - 371
反应条件
1: in N,N-dimethyl-formamide
T=50°C; 1 h; Inert atmosphere;
2: With hydrogenchloride in water; N,N-dimethyl-formamide
T=20°C;
参考文献
Levin, Vitalij V.; Dilman, Alexander D.; Belyakov, Pavel A.; Struchkova, Marina I.; Tartakovsky, Vladimir A.
Tetrahedron Letters, 2011 , vol. 52, # 2 p. 281 - 284
反应条件
tetrabutylammomium bromide in N,N-dimethyl-formamide
T=-10°C; 12 h; zinc rod anode, nickel cathode, 0.3 A;
参考文献
Sibille, S.; Mcharek, S.; Perichon, J.
Tetrahedron, 1989 , vol. 45, # 5 p. 1423 - 1428
反应条件
zinc in N,N-dimethyl-formamide
1 h; Ambient temperatureultrasonicated;
参考文献
Kitazume, Tomoya; Ishikawa, Nobuo
Chemistry Letters, 1981 , p. 1679 - 1680
反应条件
hydrogenchloride
Yield given;
参考文献
Krishnamurti, Ramesh; Bellew, Donald R.; Prakash, G. K. Surya
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 984 - 989
反应条件
1: TBAF / tetrahydrofuran / 1 h / Ambient temperature
2: 1.0 N HCl aq. / 6 h / Ambient temperature
View Scheme
参考文献
Prakash, G. K. Surya; Krishnamurti, Ramesh; Olah, George A.
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 393 - 395
反应条件
magnesium
1.) ether, RT, 2 h, 2.) RT, overnight;
参考文献
Liu, Kwang-Ting; Kuo, Mann-Yan; Shu, Ching-Fen
Journal of the American Chemical Society, 1982 , vol. 104, # 1 p. 211 - 215
反应条件
1: With copper(l) iodide in N,N-dimethyl-formamide
T=160°C; 2 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=170°C; 4 h;
参考文献
Chang, Ying; Cai, Chun
Journal of Fluorine Chemistry, 2005 , vol. 126, # 6 p. 937 - 940
