甲基(5Z)-7-[(3R)-3-羟基-5-氧代-1-环戊烯-1-基]-5-庚烯酸酯合成路线 （共 27 条）
反应条件
1: NaI / acetone
View Scheme
参考文献
Kusuda, Shinya; Watanabe, Yoshihiko; Ueno, Yoshio; Toru, Takeshi
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3145 - 3152
反应条件
1: camphorsulfonic acid / methanol
2: CBr4, triphenylphosphine / acetonitrile
3: NaI / acetone
View Scheme
参考文献
Kusuda, Shinya; Watanabe, Yoshihiko; Ueno, Yoshio; Toru, Takeshi
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3145 - 3152
反应条件
1: 1.) CuCN / 2.) THF, from -78 deg C to 0 deg C, 1 h
2: pyridinium p-toluenesulfonate (PPTS) / methanol; diethyl ether
3: CrO3, H+
5: Bu4NF
View Scheme
参考文献
Okamoto; Kobayashi; Kato; Hori; Takahashi; Tsuji; Sato
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5590 - 5592
反应条件
1: CH3SO2Cl, Et3N / CH2Cl2 / 0.67 h / 0 °C
2: 1.) CuCN / 2.) THF, from -78 deg C to 0 deg C, 1 h
3: pyridinium p-toluenesulfonate (PPTS) / methanol; diethyl ether
4: CrO3, H+
6: Bu4NF
View Scheme
参考文献
Okamoto; Kobayashi; Kato; Hori; Takahashi; Tsuji; Sato
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5590 - 5592
反应条件
1: pyridinium p-toluenesulfonate (PPTS) / methanol; diethyl ether
2: CrO3, H+
4: Bu4NF
View Scheme
参考文献
Okamoto; Kobayashi; Kato; Hori; Takahashi; Tsuji; Sato
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5590 - 5592
反应条件
1: (microbiological transformation)
2: (i) 2,4,6-trimethyl-benzenesulfonyl chloride, Et3N, (ii) Na<AlH2(OCH2CH2OMe)2>, toluene, (iii) oxalic acid, oxalic acid <Na salt>, CHCl3
View Scheme
参考文献
Heather,J.B. et al.
Tetrahedron Letters, 1973 , p. 2313 - 2316
反应条件
1: (i) NaOEt, (ii) aq. HCl
2: (microbiological transformation)
3: (i) Et3N, (ii) Al, (iii) AcOH
View Scheme
参考文献
Sih; Heather; Sood; Price; Peruzzotti; Lee
Journal of the American Chemical Society, 1975 , vol. 97, # 4 p. 865 - 874
反应条件
(i) Et3N, (ii) Al, (iii) AcOH; Multistep reaction;
参考文献
Sih; Heather; Sood; Price; Peruzzotti; Lee
Journal of the American Chemical Society, 1975 , vol. 97, # 4 p. 865 - 874
反应条件
tetrabutyl ammonium fluoride
参考文献
Okamoto; Kobayashi; Kato; Hori; Takahashi; Tsuji; Sato
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5590 - 5592
反应条件
2: Bu4NF
View Scheme
参考文献
Okamoto; Kobayashi; Kato; Hori; Takahashi; Tsuji; Sato
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5590 - 5592
