4-(苯基乙炔基)苯甲酸合成路线 （共 36 条）
反应条件
tris(dibenzylideneacetone)dipalladium (0); triphenylphosphine in N,N-dimethyl-formamide
T=80°C; Stille reaction; 10 h; Product distribution; Further Variations:ReagentsSolventseffect of DIPEA;
参考文献
Shen, Wang; Wang, Le
Journal of Organic Chemistry, 1999 , vol. 64, # 24 p. 8873 - 8879
反应条件
1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; palladium diacetate in tetrahydrofuran
Suzuki reaction; 10 h; Heating;
参考文献
Fuerstner; Leitner
Synlett, 2001 , # 2 p. 290 - 292
反应条件
hydrogenchloride
Combinatorial reaction / High throughput screening (HTS);
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE RENNES 1
Patent: US2007/43234 A1, 2007 ;
Location in patent: Page/Page column 56 ;
反应条件
in methanol; diethyl ether
0.0833333 h;
参考文献
Anderson, Kevin W.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 38 p. 6173 - 6177
反应条件
1: SPHOS; tris-(dibenzylideneacetone)dipalladium(0); tetra-n-butylammonium fluoride trihydrate / 1-methyl-pyrrolidin-2-one; water / 4 h / 50 °C
2: 1-methyl-pyrrolidin-2-one / 14 h / 80 °C
View Scheme
参考文献
Tartaggia, Stefano; De Lucchi, Ottorino; Goossen, Lukas J.
European Journal of Organic Chemistry, 2012 , # 7 p. 1431 - 1438
反应条件
triphenylphosphine in tetrahydrofuran
T=70°C; Negishi Coupling; 24 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
Wu, Wei-Yi; Lin, Tze-Chiao; Takahashi, Tamotsu; Tsai, Fu-Yu; Mou, Chung-Yuan
ChemCatChem, 2013 , vol. 5, # 4 p. 1011 - 1019
反应条件
1: KOH / butan-1-ol / Heating
2: diethyl ether
View Scheme
参考文献
Drefahl,G.; Ploetner,G.
Chemische Berichte, 1960 , vol. 93, p. 990 - 998
反应条件
1: Br2 / CCl4
2: KOH / butan-1-ol / Heating
3: diethyl ether
View Scheme
参考文献
Drefahl,G.; Ploetner,G.
Chemische Berichte, 1960 , vol. 93, p. 990 - 998
反应条件
1: palladium diacetate; triphenylphosphine; copper(l) iodide; triethylamine / tetrahydrofuran / 1 h / 20 °C / |Inert atmosphere
2: sodium hydroxide; water / ethanol / 4 h / |Reflux
3: sulfuric acid / 80 °C
View Scheme
参考文献
Phetrak, Nared; Rukkijakan, Thanya; Sirijaraensre, Jakkapan; Prabpai, Samran; Kongsaeree, Palangpon; Klinchan, Chayada; Chuawong, Pitak
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12703 - 12709
反应条件
1: sodium hydroxide; water / ethanol / 4 h / |Reflux
2: sulfuric acid / 80 °C
View Scheme
参考文献
Phetrak, Nared; Rukkijakan, Thanya; Sirijaraensre, Jakkapan; Prabpai, Samran; Kongsaeree, Palangpon; Klinchan, Chayada; Chuawong, Pitak
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12703 - 12709
