4-(苯基乙炔基)苯甲酸合成路线 （共 36 条）
反应条件
1: With sodium hydroxide; water in methanol T=70°C; 1 h; 2: in methanol; hexane; water pH=6 - 7;
参考文献
ACHAOGEN, INC.
Patent: WO2008/154642 A2, 2008 ;
Location in patent: Page/Page column 86-87 ;
WO 2008/154642 A2
反应条件
copper(l) iodide; iron; caesium carbonate; triphenylphosphine in N,N-dimethyl-formamide
T=110°C; Sonogashira coupling; 1 h; Inert atmosphere;
参考文献
Sletten, Ellen May; Bertozzi, Carolyn Ruth
Patent: US2013/244267 A1, 2013 ;
Location in patent: Paragraph 0293 ;
反应条件
piperidine; bis(η3-allyl-μ-chloropalladium(II)); tri-tert-butyl phosphine in hexane; acetonitrile
T=20°C; Sonogashira coupling; 23 h;
参考文献
Soheili, Arash; Albaneze-Walker, Jennifer; Murry, Jerry A.; Dormer, Peter G.; Hughes, David L.
Organic Letters, 2003 , vol. 5, # 22 p. 4191 - 4194
反应条件
copper(l) iodide; potassium carbonate; triphenylphosphine in dimethyl sulfoxide
T=90°C; 24 h; Inert atmosphere;
参考文献
Li, Tingyi; Sun, Peng; Yang, Hailong; Zhu, Yan; Yan, Hong; Lu, Linhua; Mao, Jincheng
Tetrahedron, 2012 , vol. 68, # 32 p. 6413 - 6419
反应条件
1: iodobenzene; acetylenecarboxylic acid With bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=50°C; 4 h;
2: 4-Bromo-benzoic acid methyl ester in dimethyl sulfoxide
T=120°C; 4 h;
参考文献
Lee, Hee Joon; Park, Kyungho; Bae, Goun; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Tetrahedron Letters, 2011 , vol. 52, # 39 p. 5064 - 5067
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran; acetonitrile
T=25°C; Sonogashira coupling; 1.5 h; Inert atmosphere;
参考文献
Man, Wing Y.; Bock, Soeren; Zaitseva, Natasha N.; Bruce, Michael I.; Low, Paul J.
Journal of Organometallic Chemistry, 2011 , vol. 696, # 10 p. 2172 - 2176
反应条件
tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine; tetrabutyl ammonium fluoride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=90°C; 12 h;
参考文献
Moon, Jeongju; Jang, Mihee; Lee, Sunwoo
Journal of Organic Chemistry, 2009 , vol. 74, # 3 p. 1403 - 1406
反应条件
triethylamine; bis(tert-butylaminophosphine)palladium(II)
T=80°C; Sonogashira cross-coupling reaction; 72 h;
参考文献
Mery, Denise; Heuze, Karine; Astruc, Didier
Chemical Communications, 2003 , # 15 p. 1934 - 1935
反应条件
MCM-41-supported mercapto palladium(0) complex in water; N,N-dimethyl-formamide
T=60°C; Stille coupling; 3 h;
参考文献
Zhao, Hong; Zheng, Guomin; Hao, Wenyan; Cai, Mingzhong
Applied Organometallic Chemistry, 2010 , vol. 24, # 2 p. 92 - 98
反应条件
tetra-(n-butyl)ammonium iodide; (Ph3P)2Pd(Ph)(I) in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=20°C;
参考文献
Bumagin, N. A.; Kalinovskii, I. O.; Ponomarev, A. B.; Beletskaya, I. P.
Doklady Chemistry, 1982 , vol. 265, p. 262 - 266
Dokl. Akad. Nauk SSSR Ser. Khim., 1982 , vol. 265, # 5 p. 1138 - 1143
