2-二乙基氨基-6-羟基-4-甲基嘧啶合成路线 （共 6 条）
反应条件
1: 2-diethylamino-4-hydroxy-6-methyl-pyrimidine With potassium carbonate in benzene 3 h; Reflux; 2: phosphorochloridothioic acid,O,O-dimethyl ester in butanone; benzene T=60 - 95°C; 2 h; Reflux;
参考文献
Farghaly; Taha; Soliman; Fathy; Bedair
Egyptian Journal of Chemistry, 2010 , vol. 53, # 6 p. 923 - 938
反应条件
citric acid in chloroform; sulfuric acid
参考文献
Imperial Chemical Industries Limited
Patent: US4080326 A1, 1978 ;
反应条件
hydrogenchloride
Heatingovernight;
参考文献
Gershon; Grefig; Clarke
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 205 - 209
参考文献
Imperial Chemical Industries Limited
Patent: US4080326 A1, 1978 ;
反应条件
1: 64 percent / ethanol / 6 h / 88 °C / stainless steel pressure vessel
2: 80 percent / 6 N hydrochloric acid / Heating; overnight
View Scheme
参考文献
Gershon; Grefig; Clarke
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 205 - 209
反应条件
sulfuric acid; nitric acid
T=20°C; 24 h;
参考文献
Li, Jiebo; Tan, Zhiwu; Tang, Shixing; Hewlett, Indira; Pang, Ruifang; He, Meizi; He, Shanshan; Tian, Baohe; Chen, Kan; Yang, Ming
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3177 - 3188
