1-(2-氨基-3-甲氧基-苯基)-乙酮合成路线 （共 7 条）
反应条件
iron; acetic acid in ethanol T=0°C; 3 h;
参考文献
NOVARTIS VACCINES and DIAGNOSTICS, INC.
Patent: WO2007/117607 A2, 2007 ;
Location in patent: Page/Page column 348 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
Alanine, Alexander; Gobbi, Luca Claudio; Kolczewski, Sabine; Luebbers, Thomas; Peters, Jens-Uwe; Steward, Lucinda
Patent: US2006/293350 A1, 2006 ;
Location in patent: Page/Page column 6 ;
US 20060293350 A1
反应条件
1: 30 percent / HNO3 / 54 h / 20 °C 2: 75 percent / Sn; aq. HCl / H2O / 4 h / Heating View Scheme
参考文献
Gabriele, Bartolo; Mancuso, Raffaella; Salerno, Giuseppe; Ruffolo, Giuseppe; Plastina, Pierluigi
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6873 - 6877
反应条件
1.1: thionyl chloride / 3 h / 75 °C 2.1: diethyl ether; ethanol / 20 °C / Reflux 2.2: 18 h / Reflux 3.1: zinc; acetic acid / tetrahydrofuran / 4 h / 0 - 20 °C View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
1: With silver hexafluoroantimonate; {RuCl2(1-methyl-4-(1-methylethyl)benzene)}2; copper (II) acetate monohydrate in 1,2-dichloro-ethane T=100°C; 24 h; Inert atmosphereSchlenk technique; 2: With sulfuric acid T=0 - 20°C; 2 h; Inert atmosphereSchlenk technique; 3: With sodium hydrogencarbonate Inert atmosphereSchlenk technique;
参考文献
Bhanuchandra; Ramu Yadav; Rit, Raja K.; Rao Kuram, Malleswara; Sahoo, Akhila K.
Chemical Communications, 2013 , vol. 49, # 45 p. 5225 - 5227
反应条件
1: in diethyl ether Heating; 2: With hydrogenchloride in diethyl ether Heating; Further stages.;
参考文献
Peters, Jens-Uwe; Luebbers, Thomas; Alanine, Alexander; Kolczewski, Sabine; Blasco, Francesca; Steward, Lucinda
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 256 - 261
反应条件
1: diethyl ether 2: P2O5; benzene View Scheme
参考文献
Alford et al.
Journal of the Chemical Society, 1952 , p. 3009,3014
