5-羟基-2-硝基苯甲醛合成路线 （共 59 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=0°C; Mitsunobu coupling;
参考文献
Renaudet, Olivier; Reymond, Jean-Louis
Organic Letters, 2004 , vol. 6, # 3 p. 397 - 400
参考文献
Fang, Yuan-Qing; Lautens, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 538 - 549
反应条件
1: 89 percent / H2O2; NaOH / H2O / 16 h / Heating
2: 76 percent / SOCl2 / 16 h / Heating
View Scheme
参考文献
Madani, Hadi; Thompson, Andrew S; Threadgill, Michael D
Tetrahedron, 2002 , vol. 58, # 40 p. 8107 - 8111
反应条件
1: 100 percent / K2CO3 / dimethylformamide / 4 h / 110 °C
2: 98 percent / KMnO4 / acetone; H2O / 5 h
View Scheme
参考文献
Giovannini; Portmann
Helvetica Chimica Acta, 1948 , vol. 31, p. 1392,1395
反应条件
1: 85 percent / K2CO3 / dimethylformamide / 16 h / 45 °C
2: 79 percent / PPh3 / CH2Cl2 / 0 - 20 °C
3: 94 percent / hydrogen / vanadium-doped platinum on carbon / methanol / 3 h / 1292.87 Torr
4: 65 percent / K3PO4*H2O; 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl / Pd(OAc)2 / toluene / 2 h / 100 °C
View Scheme
参考文献
Fang, Yuan-Qing; Karisch, Robert; Lautens, Mark
Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1341 - 1346
反应条件
1: 90 percent / SnCl2*H2O; HCl / H2O / 10 - 15 °C
2: 100 percent / NaNO2; HCl / H2O / 0 - 5 °C
View Scheme
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Hall, C.Dennis; Ji, Yu; Akhmedov, Novruz G.
Tetrahedron Letters, 2002 , vol. 43, # 18 p. 3449 - 3451
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2: toluene-4-sulfonic acid / toluene / 100 °C
3: platinum(IV) oxide; hydrogen; sodium acetate / ethyl acetate / 20 °C
View Scheme
参考文献
Caldwell, Richard D.; GUCKIAN, Kevin M.; KUMARA VEL, Gnanasambandam; LEE, Wen-Cherng; LIN, Edward Yin-Shiang; LlU, Xiaogao; MA, Bin; SCOTT, Daniel M.; SHl, Zhan; THOMAS, Jermaine; TAVERAS, Arthur G.; ZHENG, Guo Zhu
Patent: US2014/100195 A1, 2014 ;
反应条件
1: (i) aq. KOH, EtOH, (ii) /BRN= 507487/
2: (i) NH2OH*HCl, Py, (ii) Ac2O, NaOAc
3: SnCl2*2H2O, aq. HCl / acetic acid
View Scheme
参考文献
Elslager,E.F. et al.
Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 759 - 773
反应条件
1: (i) aq. KOH, EtOH, (ii) /BRN= 507487/
2: (i) NH2OH*HCl, Py, (ii) Ac2O, NaOAc
View Scheme
参考文献
Elslager,E.F. et al.
Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 759 - 773
