5-羟基-2-硝基苯甲醛合成路线 （共 59 条）
反应条件
1: Cs2CO3 / dimethylformamide
2: NaBH4 / dimethylformamide
View Scheme
参考文献
Nicolaou; Winssinger; Pastor; DeRoose
Journal of the American Chemical Society, 1997 , vol. 119, # 2 p. 449 - 450
反应条件
1: 1.) K2CO3 / 1.) THF, 1 h, 2.) THF, reflux, 24 h
2: 88 percent / tetrahydrofuran / 1.) -50 deg C, 4 h, 2.) r.t., 1 h
3: 88 percent / PDC / CH2Cl2 / 6 h / Heating
4: 97 percent / H2 / 5percent Pd/C / ethanol / 3 h / 760 Torr
View Scheme
参考文献
Fuerstner, Alois; Jumbam, Denis N.; Seidel, Guenter
Chemische Berichte, 1994 , vol. 127, # 6 p. 1125 - 1130
反应条件
in propionic acid
1 h; Heating; Further byproducts given;
参考文献
Little, Robert G.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 129 - 133
反应条件
SnCl2·2H2O in ethanol
T=90°C; reductive Friedlander reaction; 4 h; Inert atmosphere;
参考文献
Venkatesan, Hariharan; Hocutt, Frances M.; Jones, Todd K.; Rabinowitz, Michael H.
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3488 - 3491
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate
T=15 - 20°C; P=760.051 Torr; 5.5 h;
参考文献
Shionogi Co., Ltd.
Patent: EP1731502 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
参考文献
Friedlaender; Schenck
Chemische Berichte, 1914 , vol. 47, p. 3048
反应条件
sodium dithionite; water
T=90°C; Diazotieren in salzsaurer Loesung und Behandlung mit Kupfer(I)-chlorid;
参考文献
Hodgson; Beard
Journal of the Chemical Society, 1926 , p. 154
Journal of the Chemical Society, 1927 , p. 2380
反应条件
1: 84 percent / HCl gas / 12 h / Ambient temperature
2: 57 percent / Zn, aq. AcOH
View Scheme
参考文献
Albert; Hampton
Journal of the Chemical Society, 1952 , p. 4985,4990
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 4 h;
参考文献
Gan, Zhonghong; Reddy, P. Thirupathi; Quevillon, Sophie; Couve-Bonnaire, Samuel; Arya, Prabhat
Angewandte Chemie - International Edition, 2005 , vol. 44, # 9 p. 1366 - 1368
反应条件
sodium hydroxide in tetrahydrofuran; dichloromethane; water; ethyl acetate
参考文献
Roche Diagnostics GmbH; F. HOFFMANN-LA ROCHE AG
Patent: EP1542012 A1, 2005 ;
