4-甲基硫代-2-溴苯乙酮合成路线 （共 7 条）
反应条件
1: With bromine in methanol 1 h; 2: With water in methanol
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2006/66197 A1, 2006 ;
Location in patent: Page/Page column 174 ;
WO 2006/066197 A1
反应条件
1: 95 percent / AlCl3 / CHCl3 / 1 h / 0 - 10 °C 2: 90 percent / Br2 / CHCl3 / 0.5 h / 25 °C View Scheme
参考文献
Cutler et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 5475,5478
反应条件
1: 28 percent / dimethylformamide / 4 h / Ambient temperature 2: 30 percent / Br2, AlCl3 / ethyl acetate / 0.08 h / 10 °C View Scheme
参考文献
Tsuruoka, Akihiko; Kaku, Yumiko; Kakinuma, Hiroyuki; Tsukada, Itaru; Yanagisawa, Manabu; Nara, Kazumasa; Naito, Toshihiko
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 4 p. 623 - 630
反应条件
3-chloro-benzenecarboperoxoic acid T=-5 - 0°C; 3 h;
参考文献
EP1246825 B1, ;
Page 25 ;
反应条件
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in dichloromethane T=20°C; 16 h;
参考文献
Caturla, Francisco; Jimenez, Juan-Miguel; Godessart, Nuria; Amat, Merce; Cardenas, Alvaro; Soca, Lidia; Beleta, Jordi; Ryder, Hamish; Crespo, Maria I.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3874 - 3886
反应条件
potassium carbonate; 18-crown-6 ether in acetonitrile T=20°C; 3 h; Heating / reflux;
参考文献
ALMIRALL PRODESFARMA S.A.
Patent: WO2004/72057 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C; 1.33333 h;
参考文献
Deng, Xiaohu; Liang, Jimmy T.; Liu, Jing; McAllister, Heather; Schubert, Garsten; Mani, Neelakandha S.
Organic Process Research and Development, 2007 , vol. 11, # 6 p. 1043 - 1050
