(S)-2,3,4,9-四氢-1H-吡啶[3,4-b]吲哚-3-羧酸合成路线 (共 8 条)
反应条件
sulfuric acid Pictet-Spengler condensation;
参考文献
Zeng, Li; Zhang, Jianwei
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3718 - 3722
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol
参考文献
Khan, Imran A.; Saxena, Anil K.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2617 - 2626
反应条件
copper dichloride in N,N-dimethyl-formamide T=130°C; 1 h; Reagent/catalyst;
参考文献
Meesala, Ramu; Mordi, Mohd Nizam; Mansor, Sharif Mahsufi
Synlett, 2014 , vol. 25, # 1 art. no. ST-2013-D0848-L, p. 120 - 122
反应条件
triethylamine in N,N-dimethyl-formamide T=20 - 40°C;
参考文献
Liu, Jiawang; Wu, Guofeng; Cui, Guohui; Wang, Wei-Xuan; Zhao, Ming; Wang, Chao; Zhang, Ziding; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 17 p. 5672 - 5693
参考文献
Zeng, Li; Zhang, Jianwei
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3718 - 3722
反应条件
1: thionyl chloride / 24 h / 0 °C / Reflux; Inert atmosphere
2: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
View Scheme
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
反应条件
1: thionyl chloride / 24 h / 0 °C / Reflux; Inert atmosphere
2: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
3: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
4: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
5: acetic acid / water / 1 h / Reflux
View Scheme
参考文献
Ikeda, Reiko; Kimura, Takanori; Tsutsumi, Tatsuya; Tamura, Syunsuke; Sakai, Norio; Konakahara, Takeo
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3506 - 3515
反应条件
T=60°C; Substitution; pH=7.4; 120 h;
参考文献
Manabe, Shigeo; Juan, Yuan; Wada, Osamu; Ueki, Akira; Kanai, Yoshikatsu
Environmental Pollution (Amsterdam, Netherlands), 1995 , vol. 89, # 3 p. 329 - 336