hydrogenchloride in 1,4-dioxane

1: 29 percent / NH3(gas) / CHCl3 / Ambient temperature 2: HCl / dioxane View Scheme

ammonia in methanol 72 h; Ambient temperature;

hydrogenchloride in acetic acid T=37°C; 4 h; quantitative investigations, var. times;

palladium on activated charcoal; Rh on carbon; Amberlite IR 45 (acetate form); hydrogen; triethylamine; dicyclohexyl-carbodiimide 1.) DMF, 0 deg C, 4 h, 2.) aq. AcOH, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

palladium on activated charcoal; rhodium on CaCO3; hydrogen; triethylamine; dicyclohexyl-carbodiimide 1.) DMF, 0 deg C, 4 h, 2.) DMF, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

palladium on activated charcoal; hydrogen; triethylamine; dicyclohexyl-carbodiimide 1.) DMF, 0 deg C, 4 h, 2.) aq. AcOH, 72 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

Amberlyst 15; water T=100°C; 72 h;