5,6,7,8-四氢-1-萘甲酸合成路线 （共 37 条）
反应条件
1: 1) SOCl2 2: 1) BF3*THF 2) NaOH, H2O2 / 1) for 1h 2) at 50 deg C for 1h 3: 95 percent / triethylamine / CH2Cl2 / -22 °C 4: 94 percent / LiBr / dimethylformamide 5: 84 percent / Mg / tetrahydrofuran 6: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 1) BF3*THF 2) NaOH, H2O2 / 1) for 1h 2) at 50 deg C for 1h 2: 95 percent / triethylamine / CH2Cl2 / -22 °C 3: 94 percent / LiBr / dimethylformamide 4: 84 percent / Mg / tetrahydrofuran 5: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 84 percent / Mg / tetrahydrofuran 2: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 95 percent / triethylamine / CH2Cl2 / -22 °C 2: 94 percent / LiBr / dimethylformamide 3: 84 percent / Mg / tetrahydrofuran 4: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 94 percent / LiBr / dimethylformamide 2: 84 percent / Mg / tetrahydrofuran 3: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 1) TMEDA, n-BuLi / 1) in dry ether at reflux for 1h 2) -22 deg C overnight 2: 65 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 24 h / 90 °C 3: 1) TMEDA, n-BuLi / 1) in dry ether at reflux for 1h 2) CO2 as a continous stream for 1h 4: 1) SOCl2 5: 1) BF3*THF 2) NaOH, H2O2 / 1) for 1h 2) at 50 deg C for 1h 6: 95 percent / triethylamine / CH2Cl2 / -22 °C 7: 94 percent / LiBr / dimethylformamide 8: 84 percent / Mg / tetrahydrofuran 9: 72 percent / 4.5M HCl / H2O / 18 h / Heating View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: diluted Cr2O3-H2SO4 2: permanganate View Scheme
参考文献
Wightman,R.H. et al.
Journal of Organic Chemistry, 1978 , vol. 43, # 11 p. 2167 - 2170
反应条件
hydrogenchloride T=120°C; im Rohr;
参考文献
v. Braun
Chemische Berichte, 1922 , vol. 55, p. 1704
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 29
反应条件
1: NaOH / methanol / Heating 2: Raney-Ni, aq. NaOH View Scheme
参考文献
Maerkl,G. et al.
Chemische Berichte, 1962 , vol. 95, p. 2852 - 2860
反应条件
potassium hydroxide T=160 - 170°C; Trennung durch Behandeln mit Sodaloesung;
参考文献
Bamberger; Bordt
Chemische Berichte, 1889 , vol. 22, p. 630
