3-氰基-6-甲基-2-吡啶酮合成路线 （共 39 条）
反应条件
1: 6-methyl-3-cyano-2-hydroxypyridine With lithium diisopropyl amide in tetrahydrofuran; hexane T=0°C; 1 h; 2: allyl bromide in tetrahydrofuran T=0 - 23°C; Further stages.;
参考文献
Dragovich, Peter S.; Zhou, Ru; Prins, Thomas J.
Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 741 - 746
反应条件
N,N-dimethyl-formamide; trichlorophosphate 0 deg C, 1 h; 80 deg C, 5 h;
参考文献
Kasturi; Jois; Mathew
Synthesis, 1984 , vol. NO. 9, p. 743 - 746
反应条件
trichlorophosphate T=80 - 90°C; 2.5 h;
参考文献
Heterocycles, , vol. 41, # 6 p. 1307 - 1318
反应条件
1: 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-50 - 43°C; 2.25 h; 2: 1-bromo-butane in tetrahydrofuran; hexanes T=-50 - 25°C; 1 h;
参考文献
Merck and Co., Inc.
Patent: US6353110 B1, 2002 ;
Location in patent: Page column 23-24 ;
反应条件
in dichloromethane
48 h; Ambient temperature;
参考文献
Beak, Peter; Covington, Johnny B.; Smith, Stanley G.; White, J. Matthew; Zeigler, John M.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1354 - 1362
参考文献
Mariella; Havlik
Journal of the American Chemical Society, 1952 , vol. 74, p. 1915
反应条件
1: 10.5 g / phosphorus oxychloride / 2 h / Heating
2: methanol / 3 h / Heating
View Scheme
参考文献
Hassan, M. A.; Soliman, E. A.; Hamed, A. A.
Polish Journal of Chemistry, 1982 , vol. 56, # 2 p. 419 - 423
反应条件
1: 83 percent / CH2Cl2 / 48 h / Ambient temperature
2: 1.) Diisobutylaluminium hydride, 2.) 10percent aq. KOH / 1.) Toluene, -78 deg C, 30 min, 2.) RT, 3 h
View Scheme
参考文献
Beak, Peter; Covington, Johnny B.; Smith, Stanley G.; White, J. Matthew; Zeigler, John M.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1354 - 1362
反应条件
1: 83 percent / CH2Cl2 / 48 h / Ambient temperature
2: 78 percent / aq. NaOH, 30percent H2O2 / aq. ethanol / 3 h / 55 °C
3: 75 percent / aq. KOH (10percent) / H2O / 3 h / Heating
View Scheme
参考文献
Beak, Peter; Covington, Johnny B.; Smith, Stanley G.; White, J. Matthew; Zeigler, John M.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1354 - 1362
反应条件
hydrogenchloride; diisobutylaluminium hydride; 1,1,1,3,3,3-hexamethyl-disilazane
1) toluen, refl. 3 hrs., 2) -42 deg C, 6 hrs.; Yield given. Multistep reaction;
参考文献
Schowalter; Haskell
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 2 p. 367 - 370
