3-氰基-6-甲基-2-吡啶酮合成路线 （共 39 条）
反应条件
1: acetone; formic acid ethyl ester With sodium methylate in diethyl ether T=0 - 20°C; 2 h; 2: 2-cyano-acetamide With piperidinium acetate in water 2 h; Heating / reflux;
参考文献
Corvas International, Inc.
Patent: US6342504 B1, 2002 ;
Location in patent: Page column 50 ;
US 6342504 B1
反应条件
sodium methylate; piperidinium acetate; acetic acid in diethyl ether; water; acetone
参考文献
Corvas International, Inc.
Patent: US5656645 A1, 1997 ;
US 5656645 A
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C;
参考文献
Azuma, Yutaka; Morone, Mieko; Nagayama, Kouki; Kawamata, Yurie; Sato, Atsuko
Heterocycles, 2003 , vol. 60, # 6 p. 1461 - 1468
反应条件
sodium methylate in water; acetic acid; acetone
参考文献
Zeneca Limited
Patent: US5521179 A1, 1996 ;
反应条件
copper in quinoline 3 h; Heating;
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
反应条件
in 2-methoxy-ethanol; water; acetic acid
参考文献
Rohm and Haas Company
Patent: US3965107 A1, 1976 ;
反应条件
piperidinium acetate in water Cycloaddition; 0.166667 h; Heating;
参考文献
Hussain, Badria A.; Attia, Adel M.; Elgemeie, Galal E. H.
Nucleosides and Nucleotides, 1999 , vol. 18, # 10 p. 2335 - 2343
反应条件
1: 87 percent / HCl / H2O / 4 h / Heating 2: 75 percent / POCl3; PCl5 / CHCl3 / 6 h / Heating 3: 88 percent / H2 / Pd-C / methanol / 20 °C View Scheme
参考文献
Azuma, Yutaka; Morone, Mieko; Nagayama, Kouki; Kawamata, Yurie; Sato, Atsuko
Heterocycles, 2003 , vol. 60, # 6 p. 1461 - 1468
反应条件
1: 75 percent / POCl3; PCl5 / CHCl3 / 6 h / Heating 2: 88 percent / H2 / Pd-C / methanol / 20 °C View Scheme
参考文献
Azuma, Yutaka; Morone, Mieko; Nagayama, Kouki; Kawamata, Yurie; Sato, Atsuko
Heterocycles, 2003 , vol. 60, # 6 p. 1461 - 1468
反应条件
1: 98 percent / KOH / aq. ethanol / 4 h / Heating 2: 57 percent / copper powder / quinoline / 3 h / Heating View Scheme
参考文献
Mosti; Menozzi; Schenone; Dorigo; Gaion; Benetollo; Bombieri
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 5 p. 517 - 529
