2-氨基-3-甲氧基-5-溴吡啶合成路线 （共 14 条）
反应条件
1: With bromine in acetic acid T=20°C; 16.5 h; 2: With sodium hydrogencarbonate in water T=0°C; pH=7;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/81316 A1, 2011 ;
Location in patent: Page/Page column 14 ;
反应条件
1: With iron; acetic acid 2.5 h; 2: With sodium carbonate in water; ethyl acetate
参考文献
NOVARTIS AG; HUANG, Zilin; SENDZIK, Martin
Patent: WO2010/100127 A1, 2010 ;
Location in patent: Page/Page column 69-70 ;
WO 2010/100127 A1
反应条件
1.1: ethanol; water; calcium chloride; iron / 12.5 h / 75 °C 2.1: bromine / acetic acid / 16.5 h / 20 °C 2.2: 0 °C / pH 7 View Scheme
参考文献
BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas
Patent: WO2014/28669 A1, 2014 ;
Location in patent: Paragraph 00587 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine; 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide in dichloromethane T=0 - 5°C; 2: With p-toluenesulfonyl chloride in dichloromethane T=0 - 20°C; 3: With sulfuric acid in dichloromethane; water T=60 - 70°C;
参考文献
Farrell, Robert P.; Elipe, Maria Victoria Silva; Bartberger, Michael D.; Tedrow, Jason S.; Vounatsos, Filisaty
Organic Letters, 2013 , vol. 15, # 1 p. 168 - 171
反应条件
1.1: dihydrogen peroxide; trifluoroacetic acid / ethanol / 50 °C / |Sealed tube 2.1: N-ethyl-N,N-diisopropylamine; 3-keto-2H,3H-1,2-benzisothiazole 1,1-dioxide / dichloromethane / 0 - 5 °C 2.2: 0 - 20 °C 2.3: 60 - 70 °C View Scheme
参考文献
Farrell, Robert P.; Elipe, Maria Victoria Silva; Bartberger, Michael D.; Tedrow, Jason S.; Vounatsos, Filisaty
Organic Letters, 2013 , vol. 15, # 1 p. 168 - 171
反应条件
iron; acetic acid T=100°C;
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
反应条件
1: copper-powder; sodium methylate; methanol 2: chloroform 3: sulfuric acid; potassium nitrate / 35 °C 4: iron-powder; acetic acid / 100 °C View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
反应条件
1: chloroform 2: sulfuric acid; potassium nitrate / 35 °C 3: iron-powder; acetic acid / 100 °C View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
反应条件
1: sulfuric acid; potassium nitrate / 35 °C 2: iron-powder; acetic acid / 100 °C View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1171,1174
反应条件
1.1: potassium carbonate / 1 h / 20 °C / |Reflux 2.1: iron; acetic acid / 1 h / 20 °C 2.2: Py*HBr*Br2 / 20 °C View Scheme
参考文献
BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas
Patent: WO2014/28669 A1, 2014 ;
