3,4-二甲氧基-~-硝基苯乙烯合成路线 （共 36 条）
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / |Reflux
2.1: toluene / 20 h / 20 °C / |Reflux
3.1: trichlorophosphate / toluene / 4.5 h / 20 °C / |Reflux
3.2: 16 h / 0 - 20 °C
View Scheme
参考文献
Crestey, Francois; Jensen, Anders A.; Borch, Morten; Andreasen, Jesper Tobias; Andersen, Jacob; Balle, Thomas; Kristensen, Jesper Langgaard
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9673 - 9682
反应条件
zinc(II) tetrahydroborate in ethylene glycol dimethyl ether
T=0 - 5°C; 10 h;
参考文献
Ranu; Chakraborty
Tetrahedron, 1992 , vol. 48, # 25 p. 5317 - 5322
反应条件
1: silica gel, NaBH4 / CHCl3; propan-2-ol / 0.25 h / 25 °C
2: 80 percent / dimethylamine hydrochloride, KF / toluene / Heating
3: 76 percent / silica, NaBH4 / propan-2-ol; CHCl3 / 0.25 h / 25 °C
4: 60 percent / aq. chromous chloride / tetrahydrofuran / 0.17 h / Ambient temperature
View Scheme
参考文献
Kodukulla; Trivedi; Vora; Mathur
Synthetic Communications, 1994 , vol. 24, # 6 p. 819 - 832
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 0 °C / Reflux
1.2: 0 °C
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C
2.2: 8 h / 20 °C
View Scheme
参考文献
Qian, Wangke; Lu, Weijian; Sun, Haifeng; Li, Zeng; Zhu, Liyuan; Zhao, Rui; Zhang, Lei; Zhou, Shengbin; Zhou, Yu; Jiang, Hualiang; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4862 - 4871
反应条件
triethylamine
0.5 h; Heating;
参考文献
Arora, P. K.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. <B> 20, # 11 p. 951 - 954
反应条件
1,4-diaza-bicyclo[2.2.2]octane
T=40°C;
参考文献
Nyerges, Miklos; Viranyi, Andrea; Marth, Gabriella; Dancso, Andras; Blasko, Gabor; Toke, Laszlo
Synlett, 2004 , # 15 p. 2761 - 2765
反应条件
1: 64.6 percent
2: 71.7 percent / lithium aluminium hydride
3: 52 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Hocquaux; Viel; Brunaud; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 331 - 338
反应条件
1: 64.6 percent
2: 71.7 percent / lithium aluminium hydride
3: 52 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
4: 65 percent / dimethylformamide / 58 h / 100 °C
5: 70 percent / phosphorus oxychloride / benzene / 1 h / Heating
View Scheme
参考文献
Hocquaux; Viel; Brunaud; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 331 - 338
反应条件
tert.-butylhydroperoxide; n-butyllithium in tetrahydrofuran; hexane; toluene
T=-20°C; 1.5 h;
参考文献
Ashwell, Mark A.; Jackson, Richard F. W.
Synthesis, 1988 , # 3 p. 229 - 231
反应条件
1: 44 percent / methanol
2: 78 percent / H2 / Raney Ni / ethanol / 2844.3 Torr
View Scheme
参考文献
Prudhommeaux; Ernouf; Foussard Blanpin; Viel
European Journal of Medicinal Chemistry, 1975 , vol. 10, # 1 p. 19 - 28
