3-甲基-3-(4-甲基苯基)丁酸合成路线 （共 10 条）
反应条件
sodium hydroxide; bromine in 1,4-dioxane; dichloromethane; water
参考文献
PFIZER INC.
Patent: EP1334972 A1, 2003 ;
反应条件
1,4-dioxane; sodium hypochlorite; bromine weiteres Reagens: wss. NaOH;
参考文献
Bott, Garry; Field, Leslie D.; Sternhell, Sever
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5618 - 5626
反应条件
1: AlCl3 2: Br2, alkaline View Scheme
参考文献
Bott, Garry; Field, Leslie D.; Sternhell, Sever
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5618 - 5626
反应条件
1.1: CuCN / tetrahydrofuran; diethyl ether / 0 - 20 °C 1.2: 66 percent / tetrahydrofuran / 16 h / 20 °C 2.1: conc. HCl / dioxane / 18 h / Heating 3.1: 10.2 g / 1 h / 200 °C View Scheme
参考文献
Vogt; Molino; Robichaud
Synthetic Communications, 2001 , vol. 31, # 5 p. 679 - 684
反应条件
1: conc. HCl / dioxane / 18 h / Heating 2: 10.2 g / 1 h / 200 °C View Scheme
参考文献
Vogt; Molino; Robichaud
Synthetic Communications, 2001 , vol. 31, # 5 p. 679 - 684
参考文献
Vogt; Molino; Robichaud
Synthetic Communications, 2001 , vol. 31, # 5 p. 679 - 684
反应条件
potassium hydroxide T=130°C;
参考文献
Hukki
Acta Chemica Scandinavica (1947-1973), 1949 , vol. 3, p. 279,294
参考文献
Brouwers
Louvain Medical, 1974 , vol. 93, # 4 p. 189 - 194
反应条件
1: Reaktion ueber mehrere Stufen 2: 200 °C View Scheme
参考文献
Colonge; Pichat
Bulletin de la Societe Chimique de France, 1949 , p. 177,183
反应条件
(i) H2SO4, (ii) Mg, Et2O, (iii) /BRN= 1900390/; Multistep reaction;
参考文献
Ruechardt,C.
Chemische Berichte, 1961 , vol. 94, p. 2609 - 2623
