4,6-二甲氧基-1-苯并呋喃-3(2H)-酮合成路线 （共 22 条）
反应条件
potassium carbonate in methanol
T=20°C; 4 h;
参考文献
Srikrishna; Mathews
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 3 p. 383 - 385
反应条件
potassium carbonate in acetone
12 h; Heating;
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
potassium acetate in ethanol; water
8 h; Heating;
参考文献
Sharma, Anil; Chibber, S. S.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 275 - 277
反应条件
1: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
2: 85 percent / K2CO3 / acetone / 12 h / Heating
View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: 100 percent / conc. H2SO4 / 0.5 h / Ambient temperature
2: 70 percent / NBS, benzoyl peroxide / CCl4 / 12 h / 140 °C
3: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr
4: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
5: 85 percent / K2CO3 / acetone / 12 h / Heating
View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: 70 percent / NBS, benzoyl peroxide / CCl4 / 12 h / 140 °C
2: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr
3: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
4: 85 percent / K2CO3 / acetone / 12 h / Heating
View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr
2: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
3: 85 percent / K2CO3 / acetone / 12 h / Heating
View Scheme
参考文献
Kumaran, G.; Kulkarni, G. H.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 436 - 437
反应条件
1: hydrogenchloride; zinc(II) chloride / diethyl ether; water
2: hydrogenchloride; water / 1 h / 100 °C
3: sodium methylate / methanol / 1.5 h / 60 °C
4: potassium carbonate / ethylene glycol dimethyl ether / 3 h / 80 °C
View Scheme
参考文献
Haudecoeur, Romain; Ahmed-Belkacem, Abdelhakim; Yi, Wei; Fortune, Antoine; Brillet, Rozenn; Belle, Catherine; Nicolle, Edwige; Pallier, Coralie; Pawlotsky, Jean-Michel; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5395 - 5402
反应条件
in water; acetonitrile
T=30°C; influence of pH; Rate constant;
参考文献
Adams, Christopher J.; Main, Lyndsay
Tetrahedron, 1992 , vol. 48, # 45 p. 9929 - 9938
反应条件
sodium t-butanolate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; palladium diacetate in toluene
T=60 - 80°C; Buchwald coupling;
参考文献
Diedrichs, Nicole; Ragot, Jacques P.; Thede, Kai
European Journal of Organic Chemistry, 2005 , # 9 p. 1731 - 1735
