4,6-二甲氧基-1-苯并呋喃-3(2H)-酮合成路线 （共 22 条）
反应条件
1: 73 percent / Al2O3 / CH2Cl2 / 16 h / 20 °C 2: BBr3 / CH2Cl2 / 24 h / 0 - 20 °C View Scheme
参考文献
Bolek, David; Guetschow, Michael
Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 7 p. 1399 - 1403
反应条件
1: potassium hydroxide / methanol; water / Reflux 2: boron tribromide / dichloromethane / 0 - 20 °C View Scheme
参考文献
Haudecoeur, Romain; Ahmed-Belkacem, Abdelhakim; Yi, Wei; Fortune, Antoine; Brillet, Rozenn; Belle, Catherine; Nicolle, Edwige; Pallier, Coralie; Pawlotsky, Jean-Michel; Boumendjel, Ahcene
Journal of Medicinal Chemistry, 2011 , vol. 54, # 15 p. 5395 - 5402
反应条件
potassium hydroxide in methanol; water T=70°C;
参考文献
Souard, Florence; Okombi, Sabrina; Beney, Chantal; Chevalley, Severine; Valentin, Alexis; Boumendjel, Ahcne
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5724 - 5731
反应条件
potassium hydroxide in methanol T=20°C; 0.5 h;
参考文献
Souard, Florence; Okombi, Sabrina; Beney, Chantal; Chevalley, Severine; Valentin, Alexis; Boumendjel, Ahcne
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5724 - 5731
反应条件
sodium t-butanolate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; palladium diacetate in toluene T=60 - 80°C; Buchwald coupling;
参考文献
Diedrichs, Nicole; Ragot, Jacques P.; Thede, Kai
European Journal of Organic Chemistry, 2005 , # 9 p. 1731 - 1735
反应条件
potassium tert-butylate; 4-methoxy-phenol; palladacycle catalyst in toluene T=110°C;
参考文献
Souna Sido, Abdelkarim Sani; Boulenger, Loic; Desaubry, Laurent
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 8017 - 8018
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Nishida, Jun; Kawabata, Jun
Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 1 p. 193 - 202
反应条件
1: With hydrogenchloride; zinc(II) chloride in diethyl ether
2 h;
2: With water
1 h; Reflux;
参考文献
WYETH LLC; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek Suhayl; TSOU, Hwei-Ru; ZHANG, Nan; VENKATESAN, Aranapakam M.; DI, Li; KERNS, Edward H.
Patent: WO2010/30727 A1, 2010 ;
Location in patent: Page/Page column 94 ;
WO 2010/030727 A1
反应条件
Li2CO3 in water; N,N-dimethyl-formamide
参考文献
Phytera, Inc.
Patent: US6307070 B1, 2001 ;
反应条件
PPA
T=90°C; Friedal-craft acylation; 8 h;
参考文献
Sim, Hong-May; Lee, Chong-Yew; Ee, Pui Lai Rachel; Go, Mei-Lin
European Journal of Pharmaceutical Sciences, 2008 , vol. 35, # 4 p. 293 - 306
