2-氧代庚烷-1,7-二羧酸二乙酯合成路线 （共 3 条）
反应条件
2,6-dimethylpyridine; N-bromosuccinmide; silver nitrate in water; acetonitrile T=0 - 20°C; 0.5 h;
参考文献
Cushman, Mark; Yang, Donglai; Gerhardt, Stefan; Huber, Robert; Fischer, Markus; Kis, Klaus; Bacher, Adelbert
Journal of Organic Chemistry, 2002 , vol. 67, # 16 p. 5807 - 5816
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: 75 percent / hexane; tetrahydrofuran / 0.5 h / -78 - 20 °C 2.1: 41 percent / N-bromosuccinimide; silver nitrate; 2,6-lutidine / acetonitrile; H2O / 0.5 h / 0 - 20 °C View Scheme
参考文献
Burks, Elizabeth A.; Johnson Jr., William H.; Whitman, Christian P.
Journal of the American Chemical Society, 1998 , vol. 120, # 31 p. 7665 - 7675
反应条件
1: Br2 / diethyl ether / 1 h / 20 °C
2: 57 percent / ethanol
3: 85 percent / Na, Et2O
View Scheme
参考文献
Maillard; Delaunay; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 5 p. 451 - 456
